Follow-up During the Peripubertal Period of Preterm Children (Under 35 Weeks of Amenorrhea) Included in the "EPIPOD" Protocol : Evaluation of Insulin Resistance
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Preterm Children
- Sponsor
- Nantes University Hospital
- Enrollment
- 114
- Locations
- 1
- Primary Endpoint
- Insulin resistance as measured by the Triglyceride-Glucose Index
- Status
- Recruiting
- Last Updated
- 5 months ago
Overview
Brief Summary
Prematurity is associated with an increased risk of developing cardiovascular and metabolic disturbances in adulthood.
It has been demonstrated that the body composition of children born prematurely is different from that of children born under term with a deficit in fat free mass.
It can thus be wondered if this excessive adiposity does or does not predict the risk of insulin resistance in adulthood.
Children born prematurely, with a body composition measurement performed at discharge from neonatal hospitalization as part of the EPIPOD protocol, and now aged between 8 and 14 years, will be included in the INFANTPOD protocol.
Analysis of body composition, insulin resistance, renal function, pulse wave velocity, eating behaviour and of physical activity will be performed.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Children hospitalised at the Nantes University Hospital in the neonatal period
- •With a body composition measurement performed at discharge from neonatal hospitalization as part of the EPIPOD protocol
- •Born prematurely (under 35 weeks of amenorrhea)
- •Included in the Lift cohort with follow-up up to 7 years
- •Aged between 8 and 14 years at inclusion
Exclusion Criteria
- •Children with an isolated metabolic disease: insulin-dependent diabetes; endocrine disease (Cushing's, hypothyroidism)
- •Age of 15 years or more
- •with a chromosomal anomaly
- •with contraindicating measurement of the BOP-POD: ventilatory support, continuous parenteral feeding, elimination stoma
- •Refusal of either parent or child
Outcomes
Primary Outcomes
Insulin resistance as measured by the Triglyceride-Glucose Index
Time Frame: 1 day
Secondary Outcomes
- Eating behaviour using standardized french questionnaire named "QCAJE Questionnaire Comportement Alimentaire du Jeune Enfant"(1 day)
- Body composition (percentage of fat versus fat free mass) by BOP-POD and by impedancemetry (biodyXpert) for assessment of body composition variations between peripubertal period and neonatal period(1 day)
- Insulin resistance as measured by the Homeostasis Model Assessment - Insulin Resistance index(1 day)
- creatinine clearance(1 day)
- Eating behaviour using standardized questionnaire named Child Eating Behaviour questionnaire(1 day)