Cardiac Function and Metabolism in Young Adults Born Premature (PET-MRI)

Not Applicable

Completed

• Conditions: Infant,Premature

• Registration Number: NCT03245723
• Lead Sponsor: University of Wisconsin, Madison

Brief Summary

The purpose of this research is to determine the effect of premature birth on later heart function and metabolism.

Detailed Description

The purpose of this study is to determine the effects of premature birth on cardiac function, cardiac metabolism, and oxidative stress in a cohort of young adults born prematurely using cardiac positron emission tomography/magnetic resonance imaging and mitochondrial respiration studies.

Study Timeline

• Study First Submitted: 2017-08-08
• Study First Submitted QC: 2017-08-08
• Study First Posted: 2017-08-10
• Study Start: 2017-09-20
• Primary Completion: 2020-02-26
• Study Completion: 2020-02-26
• Status Verified: 2021-01
• Results First Submitted: 2021-01-14
• Results First Submitted QC: 2021-02-02
• Last Update Submitted: 2021-02-02
• Results First Posted: 2021-02-04
• Last Update Posted: 2021-02-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

• National Lung Project Cohort only- birth weight <1500g and a gestational age <36 weeks
• Adults born preterm (Non-National Lung Project) only- gestational age ≤32 weeks OR birth weight ≤ 3lbs 5oz
• Healthy Controls only- No personal history of known cardiovascular or pulmonary disease

Exclusion Criteria

• Metabolic Disorders that would affect Fludeoxyglucose uptake
• Contraindications to positron emission tomography and/or magnetic resonance imaging
• Pregnancy, if a female of child-bearing potential
• A personal history of Type I or Type II diabetes

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Cardiac Glucose Uptake During Normoxic Rest (µg/Min)	Visit 1 (1 day)	Cardiac glucose uptake will be measured via 18F-fluorodeoxyglucose (FDG) PET-MRI.
Change in Glucose Uptake From Normoxia to Hypoxia (µg/Min)	Visit 1 (1 day)	Cardiac glucose uptake will be measured via 18F-fluorodeoxyglucose (FDG) PET-MRI.

Trial Locations

Locations (1)

UW Madison; 🇺🇸 Madison, Wisconsin, United States