Cardiac Function and Metabolism in Young Adults Born Premature

University of Wisconsin, Madison1 site in 1 country52 target enrollmentSeptember 20, 2017

ConditionsInfant,Premature

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Infant,Premature
Sponsor: University of Wisconsin, Madison
Enrollment: 52
Locations: 1
Primary Endpoint: Cardiac Glucose Uptake During Normoxic Rest (µg/Min)
Status: Completed
Last Updated: 5 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this research is to determine the effect of premature birth on later heart function and metabolism.

Detailed Description

The purpose of this study is to determine the effects of premature birth on cardiac function, cardiac metabolism, and oxidative stress in a cohort of young adults born prematurely using cardiac positron emission tomography/magnetic resonance imaging and mitochondrial respiration studies.

Registry

clinicaltrials.gov

Start Date

September 20, 2017

End Date

February 26, 2020

Last Updated

5 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of Wisconsin, Madison

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•National Lung Project Cohort only- birth weight \<1500g and a gestational age \<36 weeks
•Adults born preterm (Non-National Lung Project) only- gestational age ≤32 weeks OR birth weight ≤ 3lbs 5oz
•Healthy Controls only- No personal history of known cardiovascular or pulmonary disease

Exclusion Criteria

•Metabolic Disorders that would affect Fludeoxyglucose uptake
•Contraindications to positron emission tomography and/or magnetic resonance imaging
•Pregnancy, if a female of child-bearing potential
•A personal history of Type I or Type II diabetes