Levels of High-Sensitivity C-Reactive Protein in Heart Transplant Patients

Completed

• Conditions: Heart Transplant Failure; Periodontitis; Crp
• Interventions: Other: clinical measurements

• Registration Number: NCT03671408
• Lead Sponsor: Baskent University

Brief Summary

Objectives: The outcomes of heart transplantation are very favorable but inflammation still plays a critical role in deterioration of chronic transplants. Periodontal diseases are not only limited to supporting structures of the teeth, they also cause systemic inflammation. Based on the importance of inflammation in heart transplant recipients and the association between periodontal disease and systemic inflammation, this study explored whether periodontitis may be a modifier of serum high-sensitivity C-reactive protein (HsCRP) in heart transplant patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-04-20
• Primary Completion: 2018-05-20
• Study Completion: 2018-06-10
• Status Verified: 2018-09
• Study First Submitted: 2018-09-13
• Study First Submitted QC: 2018-09-13
• Last Update Submitted: 2018-09-13
• Study First Posted: 2018-09-14
• Last Update Posted: 2018-09-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

be clinically stable be at least 1 year post-transplant; no history of antibiotic use during the preceding 4 months have had no periodontal treatment within the previous year.

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Exclusion Criteria

having other systemic infections

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
periodontitis	clinical measurements	periodontitis patients which were diagnosed based on clinical parameters
gingivitis/healthy	clinical measurements	gingivitis healthy patients which were diagnosed based on clinical parameters

Primary Outcome Measures

Name	Time	Method
hscrp levels	day 1	serum hscrp levels were compared between the groups