McArdle disease and carbohydrate ingestion before exercise: The effect of timing

Not Applicable

Completed

• Conditions: Metabolic and Endocrine - Metabolic disorders; Diet and Nutrition - Other diet and nutrition disorders; McArdle Disease; Musculoskeletal - Other muscular and skeletal disorders

• Registration Number: ACTRN12622000992707
• Lead Sponsor: Mr Sam Torrens

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-07-14
• Study Completion: 2024-02-15
• Last Update Posted: 8 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

•Previously medically confirmed MD (biopsy/genetically confirmed)
•Ambulatory and able to perform the cycling tests independently (i.e. not in a wheelchair)
•Must have the capacity to exercise intermittently for ~1 hour
•Not currently involved in or plan start any exercise regimen designed to increase aerobic capacity and be willing to remain on their current exercise regimen for the duration of the study.
•Must not have donated blood within the last 30 days and must not donate blood for the duration of the study.
•Concomitant medications (including supplements and birth control) must be stable for at least 1 month prior to enrolment and throughout participation in the study.
•Medical clearance from a General Practitioner to confirm they have medical clearance to complete the physical activity outlined in the testing protocol.
•Evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the study.

Exclusion Criteria

•Pre-existing conditions that would be aggravated by stationary cycling, such as cardiovascular diseases or musculoskeletal injury or weakness
•Type I or Type II diabetes
•Pregnant or nursing females.
•Current or prior use of anabolic steroids or other prohibited substances

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Peak heart rate achieved during each condition.[ Heart rate will be measured continuously during each 20 minute cycling trial using a Polar heart rate monitor.];Peak RPE during each condition of the 20-minute exercise trials. RPE will be measure at one minute intervals during 20 minute cycling trials using a 20 point Borg scale<br>[ RPE will be measure at one minute intervals during 20 minute cycling trials using a 20 point Borg scale];Average Heart Rate. Heart rate will be continuously measured during cycling sessions using a Polar heart rate monitor.[ ];Average Heart Rate. Heart rate will be continuously measured during cycling sessions using a Polar heart rate monitor.[ Heart rate will be recorded continuously over the course of each 20 minute trial ]

Secondary Outcome Measures

Name	Time	Method
Skeletal muscle damage will be assessed during experimental cycling sessions via blood draws for myoglobin, [ Blood draws for myoglobin analysis will take place 10 hours post second 20 minute experimental cycling sessions ];Average heart rate during each condition of the 20-minute exercise trials <br><br><br><br>[ ];Average heart rate during each condition of the 20-minute exercise trials <br><br><br><br>[ Heart rate will be recorded continuously over the course of each 20-minute trial Using a Polar heart rate monitor]