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Clinical Trials/NCT04897581
NCT04897581
Completed
Not Applicable

Establishing the Effectiveness of BBTI vs. PSR on Sleep and Pain Parameters in Adults With Musculoskeletal Orofacial Pain

Ian Boggero, PhD1 site in 1 country19 target enrollmentOctober 21, 2021

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Myofascial Pain
Sponsor
Ian Boggero, PhD
Enrollment
19
Locations
1
Primary Endpoint
Change in Self-report Quality of Life
Status
Completed
Last Updated
2 years ago

Overview

Brief Summary

This clinical study aims to compare the efficacy of two brief psychological interventions: Brief Behavioral Therapy for Insomnia (BBIT) and Physical Self-Regulation or (PSR) delivered over telehealth for the management of chronic musculoskeletal orofacial pain conditions (local myalgia, myofascial pain, centrally mediated myalgia) in a tertiary orofacial pain clinic. It is hypothesized that both interventions will produce beneficial changes and exploratory analysis will aim to establish which intervention -if any- is better for each specific outcome.

Detailed Description

New patients who come into the orofacial pain clinic are evaluated by a dental resident and given an orofacial pain diagnosis. If this primary diagnosis involves masticatory myofascial pain, local myalgia, or centrally-mediated myalgia, and if patients self-report poor sleep, they will be introduced to the study. An initial evaluation for PSR and BBTI will be scheduled over telehealth. If willing and eligible to participate, at the end of this first evaluation, they will be provided with an informed consent form and be randomly assigned to three sessions of PSR or three sessions of BBTI. After providing an e-consent, they will be sent a questionnaire battery on REDCap to assess their outcomes at pre-intervention. A REDCap daily questionnaire will be sent every day (morning and evening) starting one week before session 1 of the intervention, until two weeks after the last session. Moreover, to a small group of patients randomly selected, an actigraphy watch will be mailed. Two weeks after the last session of the intervention, a REDCap questionnaire will be sent to assess their outcomes at post-intervention. As per the current clinical protocol, all participants will be offered both interventions; only data from the first intervention will be utilized for the current study. All PSR and BBTI sessions will be conducted via telehealth using a HIPAA-compliant zoom account.

Registry
clinicaltrials.gov
Start Date
October 21, 2021
End Date
May 23, 2023
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Ian Boggero, PhD
Responsible Party
Sponsor Investigator
Principal Investigator

Ian Boggero, PhD

Assistant Professor

University of Kentucky

Eligibility Criteria

Inclusion Criteria

  • present with a score on Insomnia Severity Index \> 15
  • have a primary diagnosis of chronic (onset more than 3 months before) MSK pain (myofascial pain and/or local myalgia and/or centrally mediated myalgia) from a board-certified orofacial pain specialist at UK Orofacial Pain Clinic
  • maintain a stable medication regime in previous month and during the intervention
  • older than 18 years old
  • able to understand English
  • willing to participate to telehealth intervention
  • have internet access and an email address
  • present with total STOP BANG score \< 5

Exclusion Criteria

  • less than 18 years old
  • unable to provide informed consent

Outcomes

Primary Outcomes

Change in Self-report Quality of Life

Time Frame: At pre-intervention (1 week before starting with the intervention), post-intervention (2 weeks after the last session of the intervention)

The overall quality of life will be assessed with 12-Item Short Form Health Survey (SF-12), a 12-item questionnaire designed to measure general health by addressing eight domains: limitations in social, physical, usual role activities because of physical health and emotional problems; bodily pain; general mental health; vitality; general health perceptions. SF-12 has been shown to reflect change over time like the long form SF-36 and to demonstrate good reliability and validity . Studies have addressed the impact of orofacial pain and sleep problems on health-related quality of life. The average score of the US population is set at 50. A score below this cut-off identifies a poor self-report quality of life.

Change in Self-report Insomnia Symptoms

Time Frame: At pre-intervention (1 week before starting with the intervention) and post-intervention (2 weeks after the last session of the intervention)

Insomnia symptomatology will be assessed via the Insomnia Severity Index (ISI). The ISI includes seven items (sleep-onset, sleep maintenance, early morning awakening, satisfaction with current sleep pattern, interference with daily functioning, impairment attributed to sleep problems, distress caused by sleep problems), related to the prior 2 weeks on a five-point Likers scale (0= no problem, 4 = severe problem). The total score ranges from 0 to 28, with 28 indicating severe insomnia. The cut-off for the present study is 15. The ISI has good internal consistency and is demonstrated to be sensitive to changes in sleep of older adults following behavioral treatment for insomnia. Clinical improvement is defined as a reduction of ISI below the cut-off of 15.

Change in Self-report Average Pain Intensity

Time Frame: At pre-intervention (1 week before starting with the intervention), post-intervention (2 weeks after the last session of the intervention)

The average pain intensity will be assessed using a Numeric Rating Scale (NRS) on a 10-point scale, where 0 coincides with "no pain" and 10 coincides with "worse pain ever felt".

Secondary Outcomes

  • Change in Self-report Sleep Quality(At pre-intervention (1 week before starting with the intervention), post-intervention (2 weeks after the last session of the intervention))
  • Sleep architecture(Each morning and each evening from the first session to 2 weeks after the last session of the intervention)
  • Change in Self-report Anxiety Symptoms(At pre-intervention (one week before the first session of the intervention), at post-intervention (two weeks after the last session of the intervention) and every day during the intervention period)
  • Change in Self-report Depression Symptoms(At pre-intervention (one week before the first session of the intervention), at post-intervention (two weeks after the last session of the intervention) and every day during the intervention period)
  • Change in Self-report Headache Intensity(At pre-intervention (one week before the first session of the intervention), at post-intervention (two weeks after the last session of the intervention))
  • Change in Self-report Headache Frequency(At pre-intervention (one week before the first session of the intervention), at post-intervention (two weeks after the last session of the intervention))

Study Sites (1)

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