Effect of deferiprone on nitric oxide production in thalassemia

Not Applicable

Completed

• Conditions: Endothelium; Deferiprone; Hemoglobin E/beta- thalassemiaIron overload; Thalassemia; Nitric oxide

• Registration Number: TCTR20140807001
• Lead Sponsor: Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-08-07
• Study Completion: 2015-08-06
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Hemoglobin E beta thalassemia
Transfusion dependent thalassemia patients
No iron chelator therapy for at least 1 month before study
Clinically stable state

Exclusion Criteria

Hypersensitivity to deferiprone
Pregnancy
HIV positive
Neutropenia
Thrombocytopenia
Drug or alcohol addiction

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
nitric oxide levels in blood 0, 0.5,1,2,3,4,6 h chemiluminescence method

Secondary Outcome Measures

Name	Time	Method
ontransferrin bound iron 0, 0.5,1,2,3,4,6 h Spectrophotometry,Blood pressure 0, 0.5,1,2,3,4,6 h Sphygmomanometer