Efficacy of intravenous 100 mcg carbetocin versus intravenous 5 units oxytocin for prevention of immediate postpartum hemorrhage after normal vagina delivery among high risk prenancies; a tripple-blinded randomized controlled trial
Not Applicable
Completed
- Conditions
- pregnancynormal vaginal deliveryCarbetocinOxytocinnormal vaginal deliveryPostpartum hemorrhage
- Registration Number
- TCTR20160715004
- Lead Sponsor
- Siriraj Routine to Research Unit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 350
Inclusion Criteria
1. Thai pregnant woman
2. age at least 20 years old
3. Pregnancy age at least 34 weeks gestation
4. normal vaginal delvery
5. high risk for PPH including previous history of PPH, induction or augmentation of labour, tocolytic drug before delivery, prolonged active phase of labour, precipitate labour, grand multipara, overdistended uterus, uterine structural abnormality
Exclusion Criteria
1. being active labour
2. Contraindication to carbetocin
3. allergy to oxytocin or carbetocin
4. obstetrics complication including preeclampsia and abnormal placentation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method incidence of postpartum hemorrhage 24 hours after normal vaginal delivery percentage of immediate postpartum hemorrhage
- Secondary Outcome Measures
Name Time Method Additional uterotonic drug used after delivery 24 hours after normal vaginal delivery percentage of patient and dosage of additional uterotonic agents,Complication after delivery 24 hours after normal vaginal delivery percentage of Blood transfusion, ICU admission, Surgical management