Interdisciplinary Centenarian and Semi-supercentenarian Study in Japan Part 1: the genetic study for healthy longevity
Not Applicable
Recruiting
- Conditions
- healthy longevity
- Registration Number
- JPRN-UMIN000040446
- Lead Sponsor
- Keio University School of Medicine
- Brief Summary
1. In 535 very old individuals and 930 centenarians, the frequency of APOE E4 allele was inversely correlated with age. Additionally, APOE E4 allele in centenarian men was significantly lower than that in centenarian women. 2. In a single cell trascriptome analysis of peripheral blood mononuclear cells, derived from 7 supercentenarians and 5 younger controls, we identified identified a marked increase of cytotoxic CD4 T cells (CD4 cytotoxic T lymphocytes) as a signature of supercentenarians.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 930
Inclusion Criteria
Not provided
Exclusion Criteria
Too frail or ill to participate
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method