Interdisciplinary Centenarian and Semi-supercentenarian Study in Japan Part 2: the phenotypic and biomarker signatures for healthy longevity
Not Applicable
Recruiting
- Conditions
- healthy longevity
- Registration Number
- JPRN-UMIN000040447
- Lead Sponsor
- Keio University School of Medicine
- Brief Summary
In a cohort of 1554 individuals including 684 centenarians and semi-supercentenarians, inflammation predicted all-cause mortality in the very old and semi-supercentenarians. Inflammation predicted capability and cognition in (semi-)supercentenarians, suggesting suppression of age-related inflammatory activation is the key to healthy longevity.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 930
Inclusion Criteria
Not provided
Exclusion Criteria
Too frail or ill to participate
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method all cause and cause-specific mortality
- Secondary Outcome Measures
Name Time Method incident disability, dementia, and chronic disease of aging