The Effect of High and Low Roasted Coffee on Vascular Response

Not Applicable

Completed

• Conditions: Cardiovascular Disease
• Interventions: Dietary Supplement: Control (Caffeine dissolved in water); Dietary Supplement: Low roast coffee; Dietary Supplement: High roast coffee

• Registration Number: NCT01813981
• Lead Sponsor: University of Reading

Brief Summary

Evidence suggests that a diet rich in plant phenolic compounds may induce beneficial vascular effects. Coffee is a good source of phenolic compounds called chlorogenic acids (CGA), however the level of CGA is reduced during the roasting process.

The aim of this study is to investigate the effect of coffee roasting on vascular response. The investigators hypothesize that coffee roasted to a lesser extent will exert a favourable vascular response over more heavily roasted coffee due to the higher levels of CGA.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-05
• Primary Completion: 2011-09
• Study Completion: 2013-01
• Status Verified: 2013-03
• Study First Submitted: 2013-03-12
• Study First Submitted QC: 2013-03-14
• Last Update Submitted: 2013-03-14
• Study First Posted: 2013-03-19
• Last Update Posted: 2013-03-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 19

Inclusion Criteria

• Male
• A signed consent form
• Age 19-35 years
• Body mass index - 18.5-30 kg/m2
• Normal blood pressure at screening (< 150/90)

Exclusion Criteria

• Blood pressure > 150/90 mmHg
• Haemoglobin (anaemia marker) < 125 g/l
• Gamma GT (liver enzymes) > 80 IU/l
• Cholesterol > 6.5 mmol/l
• Had suffered a myocardial infarction or stroke in the previous 12 months
• Suffers from any reproductive disorder
• Suffers from any blood-clotting disorder
• Suffers from any metabolic disorders (e.g. diabetes or any other endocrine or liver diseases)
• Any dietary restrictions or on a weight reducing diet
• Drinking more than 21 units per week
• On any lipid-modifying medication
• On any blood pressure lowering medication
• On any medication affecting blood clotting
• Planning on altering consumption of vitamin supplements/fish oil capsules during the course of the study
• Regular or vigorous exercise (3 times/week, 20 minutes each session)
• Smoking
• Vegetarians or vegans

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
High roast coffee	Control (Caffeine dissolved in water)	110mg caffeine with 108 mg chlorogenic acid at start of study
Low roast coffee	Low roast coffee	110 mg caffeine with 235 mg chlorogenic acid at start of the study
Control	High roast coffee	110 mg caffeine at start of study

Primary Outcome Measures

Name	Time	Method
Vascular response measured by flow mediated dilatation (FMD)	Change from baseline to 2 hours

Trial Locations

Locations (2)

Department of Food and Nutritional Sciences; 🇬🇧 Reading, Berkshire, United Kingdom

University of Reading; 🇬🇧 Reading, England, United Kingdom