Title: A Comparative Study of Preoperative Carbohydrate Loading Dose and Fasting on Postoperative Recovery Time in Elective Abdominal Surgery Patients
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 144
- Primary Endpoint
- Post operative insuline resistance
Study Overview
Brief Summary
This randomized controlled trial aims to compare the effect of preoperative carbohydrate loading versus standard overnight fasting on postoperative recovery time in patients undergoing elective abdominal surgery. A total of 144 admitted patients will be randomly assigned to either receive a preoperative carbohydrate drink or follow routine fasting protocols. The primary objective is to evaluate differences in postoperative recovery time between the two groups. Secondary outcomes include length of hospital stay, postoperative complications, and patient comfort. The findings of this study may help optimize preoperative fasting guidelines and improve patient recovery outcomes.
Detailed Description
Preoperative fasting has traditionally been practiced to reduce the risk of aspiration during anesthesia; however, prolonged fasting may lead to increased insulin resistance, patient discomfort, and delayed postoperative recovery. Recent evidence suggests that preoperative carbohydrate loading may improve metabolic response and enhance recovery after surgery.
This single-center randomized controlled trial will be conducted on 144 patients admitted for elective abdominal surgery. Eligible participants will be randomly allocated into two groups: the intervention group will receive a standardized preoperative carbohydrate drink within a defined time before surgery, while the control group will follow conventional fasting guidelines.
The primary outcome of the study is postoperative recovery time, assessed using clinically relevant recovery parameters. Secondary outcomes include length of hospital stay, incidence of postoperative complications, and patient-reported comfort measures.
Data will be collected prospectively during hospital stay and analyzed to determine whether preoperative carbohydrate loading provides significant benefits over standard fasting protocols. The results of this study may contribute to improving perioperative care practices and updating fasting guidelines in surgical patients.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Supportive Care
- Masking
- None
Eligibility Criteria
- Ages
- 20 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •• Patients aged 20-60
- •ASA I-II classification.
- •Elective open or laparoscopic abdominal surgeries.
Exclusion Criteria
- •• Diabetes mellitus or impaired fasting glucose.
- •Emergency surgeries.
- •Patients with hepatic or renal dysfunction.
- •Patients on corticosteroids or insulin-sensitizing agents.
- •Pregnant patients.
Arms & Interventions
Pre operative carbohydrate Loading group
Patients in this group will receive a preoperative carbohydrate-rich clear liquid drink before elective abdominal surgery to reduce insulin resistance, improve postoperative recovery, and decrease discomfort associated with prolonged fasting.
Intervention: Patients will be given 400 mL of a carbohydrate-rich clear drink (10% daxtrosewater) approximately 2-3 hours before induction of anesthesia, according to ERAS guidelines. (Dietary Supplement)
Standard preoperative fasting group
Patients in this group will follow the routine preoperative fasting protocol as per hospital practice, including overnight fasting from solids and clear liquids according to standard anesthetic guidelines before elective abdominal surgery. No preoperative carbohydrate drink will be administered. Postoperative recovery outcomes will be compared with the intervention group receiving preoperative carbohydrate loading.
Intervention: Standard pre operative fasting (Other)
Outcomes
Primary Outcomes
Post operative insuline resistance
Time Frame: 24 hours after surgery
To evaluate the effect of preoperative oral carbohydrate loading compared with standard fasting on postoperative insulin resistance in patients undergoing elective abdominal surgery. Insulin resistance will be assessed by measuring fasting blood glucose and serum insulin levels preoperatively and postoperatively, and calculating insulin resistance using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR).
Secondary Outcomes
- Time to first oral intake(24 hours after surgery)
Investigators
Dr Muhammad asad ur rehman
Post graduate resident
Gulab Devi Hospital