Using Attention Training to Reduce Adolescents' Anxious Symptoms
- Conditions
- AnxietyAttentional Bias
- Interventions
- Behavioral: Control taskBehavioral: Attentional Bias Modification (ABM) task
- Registration Number
- NCT03973580
- Lead Sponsor
- Western University, Canada
- Brief Summary
During adolescence, youth undergo rapid developmental change and in some cases experience increases in worries and fearfulness, although the mechanisms that underlie this change are unclear. Previous studies indicate that heightened Attentional Bias (AB) toward threat-related cues may increase fearfulness, and it may be possible to change AB using a computerized, Attention Bias Modification task (ABM). This study will recruit healthy youth with elevated anxious symptoms to index attentional tendencies toward threat-related stimuli using cutting-edge techniques, and to test the effect of a computerized attention training task in altering attention to threatening cues. The investigators will also examine the role of ABM in changing youth's attention-related resting-state functional connectivity (rsFC), a neural marker of at-rest cognition.
- Detailed Description
Adolescence is a critical period for increases in anxious symptoms, potentially due to etiologically significant Attention Biases (AB) favoring threatening cues. However, the specific facets of AB that drive this vulnerability as well as their neurocognitive correlates are unclear, due in large part to the poor psychometric properties of the traditional assessment of AB in this field. By using both a standard behavioral task and a novel eye-tracking task, this study aims to unpack the nuanced facets of AB related to anxiety risks. Additionally, well-controlled Attentional Bias Modification (ABM) tasks designed to train attention away from threatening cues can be used to experimentally manipulate the causal mechanisms of interest, and to test whether ABM reduces symptoms and alters patterns of resting-state functional connectivity (rsFC, the intrinsic brain activity that occurs outside specific tasks) that characterize anxiety risks.
This study will recruit 60 11-13-year-old healthy adolescents with heightened anxious symptoms but without clinically significant anxiety disorders. They will be randomized to a six-session ABM training or a placebo task. Both before and after the training, the investigators will assess their anxious symptoms, AB, and rsFC. By examining the risk processes prior to the onset of clinically significant anxiety disorders, our work will make important new contributions to our understanding of how AB eventuates in anxiety and will have direct implications for early identification of youth at highest risk for anxiety disorders, and the targets that should be focused on in preventative efforts.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 15
- English-speaking 11-13-year-old youth without significant medical, psychological, cognitive, or language impairments.
- Adolescents with clinically significant anxiety disorders or conditions in conflict with MRI scanning (e.g., orthodontics) will be excluded.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control group Control task Participants in this arm will participate in a six-session control task, one session per week. Attentional Bias Modification (ABM) group Attentional Bias Modification (ABM) task Participants in this arm will participate in a six-session ABM task, one session per week.
- Primary Outcome Measures
Name Time Method Change from baseline in parent-reported anxious symptoms at 3 weeks follow-up 3 weeks from baseline (after completing the 3rd weekly training session) Parent-reported anxious symptoms will be assessed by the Child Behavior Checklist questionnaire. The anxious syndrome subscale will be used with a score summed across the 12 items of this subscale. Scores for each item range from 0 to 2, and scores for the subscale range from 0 to 24. Higher scores indicate greater anxious symptoms.
Change from baseline in parent-reported anxious symptoms at 6 weeks follow-up 6 weeks from baseline (after completing the 6th weekly training session) Parent-reported anxious symptoms will be assessed by the Child Behavior Checklist questionnaire. The anxious syndrome subscale will be used with a score summed across the 12 items of this subscale. Scores for each item range from 0 to 2, and scores for the subscale range from 0 to 24. Higher scores indicate greater anxious symptoms.
Change from baseline in youth self-reported anxious symptoms at 6 weeks follow-up 6 weeks from baseline (after completing the 6th weekly training session) Youth self-reported anxious symptoms will be assessed by the Youth Self Report questionnaire. The anxious syndrome subscale will be used with a score summed across the 12 items of this subscale. Scores for each item range from 0 to 2, and scores for the subscale range from 0 to 24. Higher scores indicate greater anxious symptoms.
Change from baseline in youth self-reported anxious symptoms at 3 weeks follow-up 3 weeks from baseline (after completing the 3rd weekly training session) Youth self-reported anxious symptoms will be assessed by the Youth Self Report questionnaire. The anxious syndrome subscale will be used with a score summed across the 12 items of this subscale. Scores for each item range from 0 to 2, and scores for the subscale range from 0 to 24. Higher scores indicate greater anxious symptoms.
- Secondary Outcome Measures
Name Time Method Change from baseline in response-time-indexed Attentional Bias (AB) at 6 weeks follow-up 6 weeks from baseline (after completing the 6th weekly training session) This outcome will be assessed by a behavioral dot-probe task.
Change from baseline in resting-state functional connectivity (rsFC) 6 weeks from baseline (after completing the 6th weekly training session) rsFC will be assessed by resting-state functional magnetic resonance imaging (fMRI).
Change from baseline in eye-movement-indexed Attentional Bias (AB) at 6 weeks follow-up 6 weeks from baseline (after completing the 6th weekly training session) This outcome will be assessed by an eye-tracking task.
Trial Locations
- Locations (1)
Western University
🇨🇦London, Ontario, Canada