A prospective explorative cross sectional clinical study to investigate the neurocognitive effects of human Immunodeficiency virus and the influence of highly active anti retroviral (HAART) therapy on CSF viral replication and biomarkers for neurodegeneration in HIV infected patients on chronic therapy with HAART
Completed
- Conditions
- Neuro-HIV1004743810029305
- Registration Number
- NL-OMON33642
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
• HIV-seropositive 18-65 years
• On HAART therapy
Exclusion Criteria
• Active opportunistic infection
• Active psychiatric disorder for which treatment is indicated
• Malignancy
• Neurosyphilis
• Drug addiction
• Excessive (> 2 U/d) use of alcohol
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>HIVRNA in CSF<br /><br>Drug levels, proteins and biomarkers for neurodegeneration in CSF </p><br>
- Secondary Outcome Measures
Name Time Method <p>neuropsychological abnormalities<br /><br>abnormalities in MRI of the brain</p><br>