A study to estimate the changes in serum periostin levels in adult patients, following dental extractions with or without surgery.
- Conditions
- Serum Periostin levels following dental extractionsOral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon
- Registration Number
- ACTRN12614000152628
- Lead Sponsor
- Medical Research Institute of New Zealand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 68
Aged between 18 to 75 years
Able to provide informed consent
Scheduled for dental extraction +/- surgery
Doctor’s diagnosis of Asthma, Bronchitis or COPD
Wheezing or use of respiratory inhalers in the past 12 months
Known pregnancy
Significant co morbidities (determined at investigator discretion)
Hospital admission within last 3 months
Surgery within last 3 months, determined at investigator discretion (this includes all major surgery requiring general anaesthetic, dental extractions and root canal procedures. This does not include minor procedures, including but not limited to mole or wart removal, dental fillings etc).
Oral or Systemic Corticosteroids within the last 3 months
Any other safety concern at the investigator’s discretion
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum periostin levels over a 12 week period following dental extraction[Serum Periostin levels will be measured at 7 time points: Baseline (up to 1 week prior to tooth extraction/surgery), Week 1, Week 2, Week 3, Week 4, Week 6 and Week 12 post extraction, via a specific periostin laboratory assay.]
- Secondary Outcome Measures
Name Time Method Associations between serum periostin and non-asthmatic health conditions (as captured by general health questionnaire e.g. diabetes) [Baseline (up to 1 week prior to dental extraction/ surgery)]