Contemporary Clinical Management Of Acute Pulmonary Embolism

Completed

• Conditions: Acute Pulmonary Embolism

• Registration Number: NCT03631810
• Lead Sponsor: Heart Care Foundation

Brief Summary

Acute pulmonary embolism is a potentially life-threatening disease with short-term mortality ranges from less than 1% to more than 30% during the hospital stay. Recent guidelines recommend to tailor diagnosis hospitalization and acute treatment based on the estimated risk for short-term Death.

The assessment of the contemporary clinical management of patients with acute pulmonary embolism across different specialties would be of crucial value.

Detailed Description

This is a prospective, non-interventional, multicenter study in patients with acute pulmonary embolism admitted to Cardiology, Emergency and Internal Medicine Departments in Italy.

The aim of the study is to assess contemporary management strategies in patients with acute pulmonary embolism in terms of diagnosis, risk stratification, hospitalization and treatment in Italy and assess

1. their association with in-hospital and 30-day mortality and

2. their adherence to current guidelines of the European Society of Cardiology (ESC).

Study Timeline

• Study Start: 2018-03-15
• Study First Submitted: 2018-08-13
• Study First Submitted QC: 2018-08-14
• Study First Posted: 2018-08-15
• Status Verified: 2020-02
• Primary Completion: 2021-02-04
• Study Completion: 2021-02-17
• Last Update Submitted: 2021-02-24
• Last Update Posted: 2021-02-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 5213

Inclusion Criteria

• Patients with acute, symptomatic acute pulmonary embolism
• Age ≥ 18 years
• Informed consent

Exclusion Criteria

• refusal of informed consent
• participation in controlled trials on the management of patients with acute pulmonary embolism

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
In-hospital death	30 days	In-hospital Death and Death at 30 days

Secondary Outcome Measures

Name	Time	Method
All cause Mortality and clinical worsening	30 days	Death or clinical deterioration at 30 days from the diagnosis of pulmonary embolism
Pulmonary embolism related mortality for and clinical worsening	30 days	Pulmonary embolism-related death or clinical deterioration at 30 days from the diagnosis of pulmonary embolismembolism
Adherence to guidelines	30 days	Adherence to current guidelines on the management of acute pulmonary embolism released by the ESC regarding diagnosis, risk stratification and treatment

Trial Locations

Locations (181)

Ospedale San Giovanni Di Dio - Uo Cardiologia E Utic; 🇮🇹 Agrigento, AG, Italy

Ospedali Riuniti - Sod Ps E Medicina D'Urgenza; 🇮🇹 Ancona, AN, Italy

Istituto Scientifico Inrca - Uo Cardiologia/Utic/Telecardiologia; 🇮🇹 Ancona, AN, Italy

Ospedale Madonna Del Soccorso - Medicina D'Urgenza; 🇮🇹 San Benedetto Del Tronto, AP, Italy

Ospedale Civile Ss. Filippo E Nicola - Uosd Angiologia; 🇮🇹 Avezzano, AQ, Italy

Ospedale San Donato - Medicina Interna; 🇮🇹 Arezzo, AR, Italy

Ospedale Civile - Medicina Interna; 🇮🇹 Arzignano, VI, Italy

Ospedale Valdichiana Santa Margherita - Uos Cardiologia E Hdu; 🇮🇹 Cortona, AR, Italy

Osp. Valdarno 'S. Maria Della Gruccia' - Medicina Interna; 🇮🇹 Montevarchi, AR, Italy

Ospedale Cardinal Massaia - Medicina A; 🇮🇹 Asti, AT, Italy

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