ISRCTN21363594已完成未知
A pilot randomized clinical trial of therapeutic plasma exchange (TPE) in serious SARS CoV-2 disease (COVID-19)
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 87
研究概览
简要总结
2020 Protocol article in https://doi.org/10.1186/s13063-020-04454-4 protocol (added 10/06/2020) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33838224/ (added 14/06/2023)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged =18 years
- •2. Admitted to ICU and intubated
- •3. Serious COVID-19 as per World Health Organization and Saudi Centers for Disease Control and Prevention case definition. SARS-CoV-2 infection should be confirmed by real-time polymerase chain reaction (RT-PCR) assays
- •4. At risk of cytokine release syndrome (CRS)
排除标准
- •1. Previous allergic reaction to plasma exchange reagents (e.g. sodium citrate) or equipment
- •2. Two consecutive negative RT-PCR tests for SARS-CoV-2 taken at least 24 h apart
- •3. Mild COVID-19 cases not requiring ICU admission
- •4. Terminally ill patients receiving palliative care
研究者
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