Pilot randomised controlled trial of a physiotherapist-led exercise intervention delivered prior to and during stem cell transplant in patients with myeloma

niversity College London0 sites50 target enrollmentFebruary 13, 2019

Overview

2020 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/32001493 protocol (added 03/02/2020) 2022 Other publications in https://pubmed.ncbi.nlm.nih.gov/35396313/ Protocol adaptations following COVID-19 pandemic (added 11/04/2022) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/36794394/ (added 22/02/2023) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37069548/ results from embedded qualitative semi-structured interview study (added 26/04/2023)

Registry

who.int

Start Date

February 13, 2019

End Date

September 27, 2021

Last Updated

2 years ago

Study Type

Interventional

Sex

All

Sponsor

niversity College London

•1\. Adult patients referred to the UCLH transplant multidisciplinary team (MDT) and awaiting autologous stem cell transplant as treatment for myeloma
•2\. Clinically able to carry out an exercise training programme on a regular basis
•3\. Patients must have a good command of written and spoken English
•4\. Willing and able to provide written informed consent

•1\. Patients with known spinal instability, spinal cord compression or neurological deficits
•2\. Those who have had recent (within six weeks) spinal surgery or other surgery for pathological fractures
•3\. Abnormal resting ECG and/or unstable angina
•4\. Those deemed unsuitable to partake by the MDT
•5\. Unable or unwilling to undertake an exercise programme on a regular basis