Effects of Dietary Nitrate From Vegetable/Fruit Juice on Cerebral Blood Flow Parameters
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Change from baseline cerebral blood flow
研究概览
简要总结
Nitrate provides the body with an alternative source of Nitric Oxide which plays a large role in promoting blood flow and reducing blood pressure. Nitrate supplementation with vegetable/fruit juice has recently been shown to reduce blood pressure and reduce energy expenditure during low intensity exercise. Such findings combined with the previously known biological effects of nitric oxide would suggest that nitrate supplementation would also impact on blood flow. The aim of this study is to examine the effects of dietary nitrate supplementation via vegetable/fruit juice drink on cerebral (brain) blood flow (using Near Infrared Spectroscopy).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy young (18-35 years) male and female adults, not vulnerable.
排除标准
- •smoke or consume any tobacco products (even occasionally)
- •not proficient in English
- •pregnant (or are seeking to become)
- •currently taking recreational, over the counter/prescription medication (excluding the contraceptive pill), and/or dietary/herbal supplements.
- •any food allergies or sensitivities that are relevant to the study
- •history of/current head trauma, learning difficulties, ADHD, dyslexia, migraines or any gastric problems.
研究组 & 干预措施
Vegetable/ Fruit juice
450ml active product, 45 ml no added sugar squash (for flavour)
干预措施: Vegetable/fruit juice (Dietary Supplement)
Placebo juice
干预措施: Placebo juice (Dietary Supplement)
结局指标
主要结局
Change from baseline cerebral blood flow
时间窗: From baseline to 2.5 hours post-dose
Near infrared spectroscopy monitoring of cerebral blood flow in the frontal cortex during demanding tasks. Monitored from baseline, through 90 minutes of drink absorption and 60 minutes of cognitive task performance.
Change from baseline cognitive function
时间窗: 90 minutes post-dose
Performance of the cognitive demand battery (CDB), which assesses aspects of psychomotor speed, working memory and executive function. The CDB involves 6 repetitions of the following tasks: serial three subtractions (2 mins); serial seven subtractions (2 mins); Rapid Visual Information Processing (5 mins) and a subjective rating of mental fatigue
Change from baseline mood
时间窗: 2.5 hours post-dose
Bond-Lader visual analogue mood scales assessing the mood factors 'alert'; 'calm'; and 'content'
次要结局
- Change from baseline blood pressure, heart rate and venous nitrate and nitrite levels(2.5 hours post-dose)