NCT02877784已完成不适用
Determination of Accurate Screening Tools for Dysphagia in Oculopharyngeal Muscular Dystrophy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- Dynamic Imaging Grade of Swallowing Toxicity
研究概览
简要总结
Oculopharyngeal muscular dystrophy (OPMD) is a rare myopathic disease that results in progressive degeneration of the oral and pharyngeal muscular, resulting in severe dysphagia and dysarthria. OPMD is considered a rare disease; therefore, limited research is available on the natural progression of the disease or the utility of biomarkers to identify swallowing impairment. The aim of this study is:
- To identify accurate, reliable and non-invasive clinical markers of swallowing impairment
- To determine the discriminate ability of these markers to identify impairments in swallow safety and swallowing efficiency.
详细描述
Participants will be recruited from the Neurology clinic at the University of Florida. The single evaluation will occur in the PIs research laboratory at the University of Florida, Gainesville, Florida.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of oculopharyngeal muscular dystrophy
- •no allergies to barium or capsaicin,
- •no tracheotomy or mechanical ventilation
- •no significant concurrent respiratory disease (e.g., COPD).
排除标准
- •Pregnant Women
结局指标
主要结局
Dynamic Imaging Grade of Swallowing Toxicity
时间窗: Baseline
Global Metric of swallowing Safety and Efficiency
次要结局
- Dietary intake as confirmed by Functional Oral Intake Scale (FOIS)(Baseline)
- Participant perception of swallowing related symptoms as confirmed by The Eating Assessment Tool 10 (EAT-10)(Baseline)
研究者
研究点 (1)
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