ISRCTN11916601
Completed
未知
A prospective, single-centre pilot trial to evaluate the feasibility and safety of ultrasound-guided direct portal vein pressure gradient measurement in patients with non-neoplastic hepatic disorders
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Kantonsspital St. Gallen
- Enrollment
- 18
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Patient planned to undergo transient elastography and percutaneous liver biopsy via the right lobe of the liver in frame of standard diagnostics for non\-neoplastic hepatic disorders regardless of the stage of fibrosis
- •2\. Patient available for planned follow\-up for at least 1 month
- •3\. Male or female aged \=18 years
- •4\. Must be willing and able to give written informed consent to participate in the study and agree to comply with the study protocol prior to initiation of any study\-mandated procedure and study intervention
Exclusion Criteria
- •1\. Patient with primary neoplastic hepatic disorders and/or liver metastasis
- •2\. Patient planned to undergo biopsy of a focal liver lesion or biopsy via the left lobe of the liver
- •3\. Patient on any anticoagulation therapy at the time point of liver biopsy that cannot be stopped prior to actual conduct of liver biopsy
- •4\. Patient having coagulation disorder defined as INR \=1\.5 and thrombocytes \=70 G/l
- •5\. Patient with Body Mass Index (BMI) \=35
- •6\. Patient with ascites
- •7\. Patient with known allergies to ultrasound contrast agent SonoVue®
- •8\. Patient with known right\-to\-left shunts, severe pulmonary hypertension (pulmonary arterial pressure \> 90 mmHg), uncontrolled systemic hypertension or Respiratory Distress Syndrome (ARDS)
- •9\. Patient on dobutamine therapy
- •10\. Patient allergic to porcine collagen
Outcomes
Primary Outcomes
Not specified
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