KCT0005991
Completed
未知
Prospective, multicenter, pilot study to evaluate the effectiveness of biomarkers for early diagnosis of acute rejection in de novo renal transplant recipients
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Kyungpook National University Hospital
- Enrollment
- 40
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\) Newly kidney transplant recipient
- •2\) Aged from 18 to 75
- •3\) High risk of acute rejection (one or more of the following is satisfied)
- •HLA mismatch \=5
- •Pretransplant panel reactive antibody \=30%
- •Pretransplant desensitization
- •Positive for direct cross match
- •Extended criteria deceased donor kidney transplantation
- •4\) Induction immunosuppression using anti\-thymocyte globulin or basiliximab,and maintenance immunosuppression by tacrolimus, mycophenolic acid and steroid
Exclusion Criteria
- •1\) Active infection
- •2\) HIV, HCV infection
- •3\) Comorbid untreatable ischemic heart disease
- •4\) Abnormality of hematologic exam (hemoglobin \<7\.0g/dL, leukocyte count \<2,500/mm3, absolute neutrophil count \<1,500/mm3, platelet count \<75,000/mm3\)
- •5\) Pregnant
- •6\) Multiorgan trasnplant
- •7\) History of malignancy
Outcomes
Primary Outcomes
Not specified
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