Onderzoek naar voeding en de hersene
Recruiting
- Conditions
- ObesityGut-brain-axis
- Registration Number
- NL-OMON28668
- Lead Sponsor
- Academic Medical Center (AMC), Amsterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
Ability to provide informed consent;
- Age: 50-70 years
Exclusion Criteria
-Use of any medication except for those related to treatment of components of the metabolic syndrome (not including insulin, oral glucose lowering drugs, alpha- and beta-blockers)
-Any actual medical condition except for treated hypothyroidism and the metabolic syndrome
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The effect of intragastric infusion of nutrients on:<br /><br>- Brain activity assessed as the induced change in fMRI signal and resting state brain connectivity measured with fMRI.<br /><br>- Striatal dopamine response, measured as the change in D2/D3R binding potential of IBZM assessed by SPECT. <br>
- Secondary Outcome Measures
Name Time Method The effect of intragastric infusion of nutrients on:<br /><br>- Glucoregulatory and gut hormone release<br /><br>- Objective scores of hunger and satiety during a buffet test meal after the infusion of the nutrients.<br /><br>- Subjective (VAS) scores of hunger and satiety<br /><br>- Neuropsychological functioning and feeding behaviour characteristics assessed by questionnaires and tasks<br>