Gastric digestion and post-prandial absorption of infant formula differing in protein composition, particularly in whey and casein composition.
- Conditions
- fysiologienomal digestionphysiology
- Registration Number
- NL-OMON51077
- Lead Sponsor
- Wageningen Universiteit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Male
Age 18 * 45 y
Healthy (self-reported)
Normal-weight (BMI 18.5 * 25kg/m2)
Willing to be informed about incidental findings of pathology
Willing to comply with the study procedures
Allergy or intolerance for cow milk, lactose, soy and/or fish (self-reported)
Gastric disorders or regular gastric complaints, for example heart burn
Use of medication which alters the normal functioning of the stomach, such as:
Medical drug use that influences the GI tract's normal function (e.g. motility,
pH, etc.) or the GI tract's microbiota (e.g. antibiotics).
Smoking (>2 cigarettes a week)
Drinking more than 14 glasses of alcohol a week
Having given a blood donation in the past two months
Hb value below 8.4 mmol/L (as measured with finger-prick method)
Having contra-indication to MRI scanning (e.g. having a pacemaker,
defibrillator, intraorbital or intraocular metallic fragments, ferromagnetic
implants, or being claustrofobic)
Participating in other research during the study period
Not having a general practitioner or unwillingness to share unexpected findings
with the general practitioner
Being an employee or student of the division of human nutrition and health
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Top layer volume of the stomach contents</p><br>
- Secondary Outcome Measures
Name Time Method <p>Total gastric content volume and blood parameters ((NMR-based) metabolomics<br /><br>(focusing on the lipid metabolism), plasma free fatty acids, glucose &<br /><br>insulin). </p><br>