Gastric digestion and postprandial amino acid absorption of pea protein: effect of heat treatment and viscosity

Completed

• Conditions: eiwitvertering bij gezonde mensen; normal digestion

• Registration Number: NL-OMON55330
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

• Male
• 18 - 55 yr old
• In self-reported health
• BMI between 18,5 and 25kg/m2

Exclusion Criteria

• Pea protein allergy (self-reported)
• Disorders of the upper ingestive tract resulting in difficulties
chewing/swallowing.
• Unexplained weight change >5 kg in the month within 1 month prior to the
pre-study screeningsday
• Gastric disorders or regular gastric complaints, heart burn for example
• Use of proton pump inhibitors or other medication which alters the normal
functioning of the stomach
• Use of a medical drug use that influences the GI tract*s normal function,
e.g. the motility, pH etc: among others use of proton pump inhibitors,
antacids, anti-depressants etc.
• Use of a medical drug use that influence the GI tract*s microbiota:
antibiotic use within 1 months prior to the pre-study screenings day
• use of recreational drugs within 1 month prior to the pre-study screenings day
• alcohol consumption of more than 14 glasses/week
• Smoking (>2 sigarettes a week)
• Having a contra-indication to MRI scanning (including, but not limited to):
* Pacemakers and defibrillators
* Intraorbital or intraocular metallic fragments
* Ferromagnetic implants
* Claustrofobic
• Not wanting information at unexpected findings
• Use of protein supplements during the study
• Following a medical diet
• Being an employee or student of the Division of Human Nutrition and health
•Having donated blood in the two months preceding the first visit
•Hb value below 8.4 mmol/L (as measured with finger-prick method)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Gastric content volume over time, postprandial plasma amino-acid<br /><br>concentrations.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Intra-gastric processes (coagulation, emulsion stability), MRI markers (T2, MT) </p><br>