Gastric digestion and amino acid absorption of pea protei
- Conditions
- 'Gastric emptying' 'amino acid absorption'
- Registration Number
- NL-OMON28566
- Lead Sponsor
- Wageningen University
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 12
• Male
• Age 18 – 55 y
• Apparently healthy
• Normal-weight (BMI 18.5 – 25)
• Pea protein allergy (self-reported)
• Gastric disorders or regular gastric complaints such as heart burn
• Use of medication which alters the normal functioning of the stomach, such as:
o medical drug use that influences the GI tract’s normal function, e.g. the motility, pH etc: among others use of proton pump inhibitors, antacids, anti-depressants etc. (judged by our study doctor)
o Medical drug use that influence the GI tract’s microbiota: e.g. antibiotic use within 1 months prior to the pre-study screenings day (judged by our study doctor)
• Use of recreational drugs within 1 month prior to the pre-study screenings day
• Alcohol consumption of more than 14 glasses/week
• Use of protein supplements during the study
• Following a medical diet
• Participating in other biomedical research during the study period
• Smoking (>2 cigarettes a week)
• Having donated blood in the two months preceding the first visit • Hb value below 8.4 mmol/L (as measured with finger-prick method)
• Having a contra-indication to MRI scanning (including, but not limited to):
? Intraorbital or intraocular metallic fragments
? Ferromagnetic implants
? Claustrofobia
• Not having a general practitioner or unwillingness to share chance findings of pathology with the general practitioner
• Being an employee or student of the Division of Human Nutrition and health
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Post-prandial serum amino-acid concentration<br>2. Gastric emptying rate
- Secondary Outcome Measures
Name Time Method 1. Postprandial glucose and insulin levels<br>2. Gastric layer formation and other product instabilities if visible<br>3. Fullness, bloating, nausea ratings obtained after each MRI measurement