Postprandial amino acid uptake kinetics of barley rice proteins
- Conditions
- opname van aminozurenamino acid uptake kinetics
- Registration Number
- NL-OMON51345
- Lead Sponsor
- Wageningen Food and Biobased Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 12
* Apparently healthy men and women;
* Age between 18 and 40 years;
* Body mass index (BMI) between 18.5 and 30 kg/m2 ;
* Having veins suitable for blood sampling via a catheter (judged by study
nurse/ medical doctor).
* Any metabolic, gastrointestinal, inflammatory or chronic disease (such as
diabetes, anaemia, hepatitis, cardiovascular disease),or having a condition or
disease that may lead to an impaired immune system;
* History of gastrointestinal surgery or having (serious) gastrointestinal
complaints;
* History of liver dysfunction (cirrhosis, hepatitis) or liver surgery;
* Kidney dysfunction (self-reported);
* Any use of medication that may suppress the immune system, this will be
judged by the medical supervisor;
* Use of medication that may influence the study results, such as gastric acid
inhibitors, laxatives, stomach protectors and drugs that can affect intestinal
motility, this will be judged by the medical supervisor;
* Anaemia (Hb values <7.5 mmol/L for women and <8.5 mmol/L for men);
* Reported slimming, medically prescribed or other extreme diets;
* Use of protein supplements;
* Not willing to give up blood donation during the study;
* Current smokers;
* Alcohol intake *4 glasses of alcoholic beverages per day;
* Pregnant, lactating or wishing to become pregnant in the period of the study
(self-reported);
* Abuse of hard drugs;
* Having food allergies and/or intolerances (e.g. for gluten);
* Not having a general practitioner;
* Participation in another clinical trial at the same time;
* Being an employee of the department Food, Health & Consumer Research of
Wageningen Food & Biobased Research.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are total amino acid (AA) and essential amino acid<br /><br>(EAA) uptake kinetics e.g. the appearance of free amino acids in blood samples<br /><br>collected before and after the postprandial protein load.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Plasma glucose and insulin levels will be determined before and after<br /><br>postprandial protein load </p><br>