Protein digestion and amino acid absorption in the aging gastrointestinal tract

• Conditions: Anabolic resistance; protein malabsorption; 10017943; 10037008

• Registration Number: NL-OMON56736
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 38

Inclusion Criteria

- Aged 18-35 years or 67+ years
- Body mass index (BMI) 18.5-30 kg/m2
- Regular stool frequency ranging from 1-3 times/day

Exclusion Criteria

- History of cardiovascular, respiratory, gastrointestinal, urogenital,
neurological, psychiatric, dermatologic, musculoskeletal, metabolic, endocrine,
haematological, immunologic disorders, allergy, major surgery and/or laboratory
assessments which might limit participation in or completion of the study
protocol, interfere with the execution of the experiment, or potential
influence the study outcomes (to be decided by the principal investigator and
responsible physician)
- Major abdominal surgery interfering with gastrointestinal function (upon
judgement of the principal investigator and responsible physician)
- Use of medication which limit participation in or completion of the study
protocol, interferes with the execution of the experiment, or potential
influences the study outcomes (to be decided by the principal investigator and
responsible physician) including but not limited to chronic use of
anticoagulants, regular use of laxatives 14 days prior to the study or during
the study period, use of antibiotics 3 months prior to the study or during the
study period
- Use of supplementation (i.e. vitamin, pre- and probiotic supplementation,
protein) within 14 days prior to testing
- Administration of investigational drugs or participation in any scientific
intervention study prior to or during the study period, which may interfere
with this study (upon judgement of the principal investigator and responsible
physician)
- Specific diet (e.g. vegetarian, vegan, gluten free, no diary) within the
study period
- Planning to lose weight during the study period
- Excessive alcohol consumption (defined as > 14 alcoholic consumptions per
week)
- Smoking
- Drug use
- Pregnancy
- Donated blood three months prior to the test day
- No given permission to register participation in electronic patient file at
MUMC+ and to add records of gastroduodenoscopy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified