Digestion and absorption of coagulated casei
- Conditions
- <tr><td>Healthy males - there was no health condition</td></tr>'gastric emptying' 'amino acid absorption'10017977
- Registration Number
- NL-OMON20073
- Lead Sponsor
- FrieslandCampina
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 15
• Male • Age 18 – 55 y • Healthy • Normal-weight (BMI 18.5 – 25)
• Cow milk allergy or intolerance (self-reported) • Lactose intolerance (self-reported) • Gastric disorders or regular gastric complaints, heart burn for example • Use of proton pump inhibitors or other medication which alters the normal functioning of the stomach, such as: o medical drug use that influences the GI tract’s normal function, e.g. the motility, pH etc: among others use of proton pump inhibitors, antacids, anti-depressants etc. o Medical drug use that influence the GI tract’s microbiota: antibiotic use within 1 months prior to the pre-study screenings day • Use of recreational drugs within 1 month prior to the pre-study screenings day • Alcohol consumption of more than 14 glasses/week • Being vegan • Participating in other research • Smoking • Having given a blood donation in the past 2 months • Having a contra-indication to MRI scanning (including, but not limited to): ? Pacemakers and defibrillators ? Intraorbital or intraocular metallic fragments ? Ferromagnetic implants ? Claustrofobia • Not having a general practitioner or unwillingness to share unexpected findings with the gen-eral practitioner
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. Postprandial plasma amino-acid concentrations 2. Gastric emptying rate</p><br>
- Secondary Outcome Measures
Name Time Method <p>1. Postprandial glucose and insulin levels 2. Gastric layer formation and other product instabilities if visible 3. Fullness, bloating, nausea ratings obtained after each MRI measurement</p><br>