The effect of oral ingestion of casein protein versus whey protein on plasma amino acids, satiety and anorexigenic hormones after gastric bypass surgery

Completed

Conditions: Obesitas
fullness
satiety
10043413

Registration Number: NL-OMON44185

Lead Sponsor: Medisch Centrum Leeuwarden

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 18

Inclusion Criteria

Female
Gastric bypass surgery at age 18-65 years
Primary gastric bypass between 12 and 18 months ago

Exclusion Criteria

Follow-up is not feasible
Known allergies or intolerance to ingredients used in the intervention product
Medicine usage known to influence dietary uptake and/or appetite
Pregnancy
Hypo- or hyperthyroidism
Known malabsorption syndrome
Known heart failure
Known renal insufficiency or failure
Known severe hepatic disease
Known severe symptomatic post gastric bypass hypoglycaemia
Active Diabetes Mellitus or remission
Former gastric operations

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- To assess and compare the net incremental area under the curve of<br /><br>satiety-related plasma amino acids and derivatives (i.e. Alanine, Arginine,<br /><br>Asparagine, Glutamine, Glycine, Histidine, Lysine, Phenylalanine, Serine,<br /><br>Taurine, Threonine, a-aminobutyric acid) in response to lactase-containing milk<br /><br>supplemented with either casein or whey protein in a randomized controlled<br /><br>cross over study in subjects 12-18 months after primary gastric bypass surgery. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- To assess and compare the effect of the ingestion of both protein supplements<br /><br>in lactase-containing milk on plasma concentrations of all amino acids and<br /><br>derivatives, plasma concentrations of anorexigenic gastrointestinal hormones<br /><br>PYY and GLP-1, satiety, hunger, dumping symptoms, heart rate, blood pressure,<br /><br>glucose metabolism and ad libitum food intake after completion of the test meal<br /><br>in a randomized controlled cross over study in subjects 12-18 months after<br /><br>primary gastric bypass surgery.<br /><br><br /><br>- To assess the self-reported dietary patterns, macronutrient consumption,<br /><br>energy intake, eating behaviour and physical activity measured by<br /><br>questionnaires in subjects 12-18 months after primary gastric bypass surgery.</p><br>