Gastric casein coagulation and post prandial amino acid absorption: effect of the product matrix
- Conditions
- eiwitvertering bij gezonde mensennormal digestion
- Registration Number
- NL-OMON49160
- Lead Sponsor
- Wageningen Universiteit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 15
* Male
* 18 - 55 yr old
* In self-reported health
* BMI between 18,5 and 25kg/m2
* Bovine milk allergy or intolerance (self-reported)
* Being vegan
* Lactose intolerance (self-reported)
* Disorders of the upper ingestive tract resulting in difficulties
chewing/swallowing.
* Unexplained weight change
* Gastric disorders or regular gastric complaints, heart burn for example
* Use of proton pump inhibitors or other medication which alters the normal
function-ing of the stomach
* Use of a medical drug use that influences the GI tract*s normal function,
e.g. the motility, pH etc: among others use of proton pump inhibitors,
antacids, anti-depressants etc.
* Use of a medical drug use that influence the GI tract*s microbiota:
antibiotic use within 1 months prior to the pre-study screenings day
* Use of recreational drugs within 1 month prior to the pre-study screenings
day
* Alcohol consumption of more than 14 glasses/week
* Smoking
* Having a contra-indication to MRI scanning (including, but not limited to):
* Pacemakers and defibrillators
* Intraorbital or intraocular metallic fragments
* Ferromagnetic implants
* Claustrofobic
* Not wanting information at unexpected findings
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. Postprandial plasma amino-acid concentrations<br /><br>2. Gastric emptying rate</p><br>
- Secondary Outcome Measures
Name Time Method <p>1. Glucose and insulin<br /><br>2. Coagulation and other product instabilities if visible<br /><br>3. Fullness, bloating, nausea ratings obtained after each MRI measurement</p><br>