Perioperative Muscle Relaxant and Postoperative Outcomes
- Conditions
- Postoperative Complications
- Interventions
- Other: 1-2 Response to Train of Four StimulationOther: No Response to Train of Four Stimulation
- Registration Number
- NCT04371588
- Lead Sponsor
- Air Force Military Medical University, China
- Brief Summary
Muscle relaxant is usually needed for surgery. However, the optimal depth of neuro-muscular blockade is still on debate. Deep neuro-muscular blockade may benefit the patients during surgery, but may increase the risk of residual blockade after surgery. Residual blockade has been reported to increase risk of morbidity. In this study, we tend to observe the postoperative outcomes in patients undergoing abdominal surgery under general anesthesia. And to compare the outcomes in patients received different depth of neuro-muscular blockade.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 999
- Age ≥18 years old
- Body mass <18 kg/m2
- American Society of Anesthesiologists status I-II
- Patients scheduled for elective laparoscopic colorectal or urological surgery
- Patients received general anesthesia and muscle relaxant
- Patients with written informed consent.
- Second surgery during the same admission.
- Outpatient surgery
- Retroperitoneal laparoscopic surgery
- Patients scheduled for mechanical ventilation after surgery
- Patients scheduled for muscle relaxant other than rocuronium
- Patients with pregnancy or planned for breeding
- Patients who are involved in other studies
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Moderate neuro-muscular blockade 1-2 Response to Train of Four Stimulation - Deep neuro-muscular blockade No Response to Train of Four Stimulation -
- Primary Outcome Measures
Name Time Method Visual Analogue Scale of pain at rest at 24 hours after surgery from end of surgery to 24 hours after surgery The intensity of pain is reported by the patient by provide a number between 0 and 10. 0 means no pain, and 10 means unbearable pain. Higher score means stronger pain.
Visual Analogue Scale of pain at cough at 24 hours after surgery from end of surgery to 24 hours after surgery The intensity of pain is reported by the patient by provide a number between 0 and 10. 0 means no pain, and 10 means unbearable pain. Higher score means stronger pain.
- Secondary Outcome Measures
Name Time Method Time to flatus from end of surgery to flatus, on an average of 3 days Time to extubation of the endotracheal tube from end of surgery to removal of the endotracheal tube, on an average of 15 minutes Incidence of patients suffering pain at 24 hours after surgery from end of surgery to 24 hours after surgery Incidence of major postoperative complications from end of surgery to discharge from the hospital, on an average of 5 days Incidence of major postoperative complications (including myocardial ischemia, pulmonary infection, respiratory failure, brain ischemia)
Satisfaction score of the Surgeon to the condition during surgery from start of surgery to end of surgery, on an average of 2.5 hours The satisfaction of the Surgeon is measured by a scale from 0-10. 0 is for extremely unsatisfied, 10 is for totally satisfied. Higher score means higher satisfaction. The surgeon is asked to give a number between 0 and 10 to describe his satisfaction.
Trial Locations
- Locations (9)
Tongji Hospital of Tongji Medical School
🇨🇳Wuhan, Hubei, China
Ruijin Hospital
🇨🇳Shanghai, Shanghai, China
People's Hospital of Jiangsu
🇨🇳Nanjing, China
First Afiliated Hospital of Zhengzhou University
🇨🇳Zhengzhou, Henan, China
Xiehe Hospital of Fujian Medical University
🇨🇳Fuzhou, Fujian, China
First hospital of Beijing University
🇨🇳Beijing, Beijing, China
Xiehe Hospital of Tongji Medical School
🇨🇳Wuhan, Hubei, China
General hospital of Tianjin Medical University
🇨🇳Tianjin, Tianjin, China
Huaxi Hospital
🇨🇳Chengdu, Sichuan, China