Residual Neuromuscular Block in the Post-Anesthetic Unit and Postoperative Complications

Recruiting

• Conditions: Postoperative Neuromuscular Block; Postoperative Complications
• Interventions: Diagnostic Test: Train-of-four

• Registration Number: NCT06386354
• Lead Sponsor: Dr. Negrin University Hospital

Brief Summary

The use of neuromuscular blockers (NMB) is essential to optimize surgical conditions, ensure patient immobility during the intervention and prevent complications derived from involuntary movements. Intraoperative monitoring of neuromuscular relaxation allows the depth of neuromuscular blockade to be accurately evaluated, guaranteeing ideal conditions for the surgical team. Residual neuromuscular blockade (RNMB) is the persistence of muscle paralysis after the administration of NMB during a surgical intervention. The appearance of RNMB poses substantial challenges in the postoperative period, as it has negative repercussions for the safety and well-being of the patient.

Detailed Description

The use of neuromuscular blockers (NMB) is essential to optimize surgical conditions, ensure patient immobility during the intervention and prevent complications derived from involuntary movements. Intraoperative monitoring of neuromuscular relaxation allows the depth of neuromuscular blockade to be accurately evaluated, guaranteeing ideal conditions for the surgical team. Residual neuromuscular blockade (RNMB) is the persistence of muscle paralysis after the administration of NMB during a surgical intervention. The appearance of RNMB poses substantial challenges in the postoperative period, as it has negative repercussions for the safety and well-being of the patient. In this prospective observational study, all patients who underwent general anesthesia with neuromuscular blockade were studied consecutively for one month to evaluate the presence of residual neuromuscular blockade and its potential consequences during hospital admission. .

Study Timeline

• Study First Submitted: 2024-04-23
• Study First Submitted QC: 2024-04-23
• Study First Posted: 2024-04-26
• Study Start: 2024-05-01
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-08
• Last Update Posted: 2024-10-10
• Primary Completion: 2024-10-30
• Study Completion: 2024-10-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patient undergoing surgical intervention under general anesthesia that requires the use of neuromuscular block during the study time and that required hospital admission.
• Informed consent signature.

Exclusion Criteria

• Neuromuscular disease
• Not having received neuromuscular block during the intervention
• Admission to the outpatient surgery unit
• Admission to the postoperative intensive care unit
• Patients who signed informed consent, but postoperative data could not be collected upon arrival at the PACU.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients submitted to General Anesthesia with Neuromuscular Block	Train-of-four	Patients submitted to General Anesthesia with Neuromuscular Block

Primary Outcome Measures

Name	Time	Method
Residual Neuromuscular Block	8 minutes postoperatively	Train-Of-Four ratio 3 minutes after the arrival to the Post-Anesthetic Care Unit

Secondary Outcome Measures

Name	Time	Method
Postoperative complications	30 days postoperatively	Postoperative complications during hospital admission

Trial Locations

Locations (2)

Hospital Universitario de Gran Canaria Doctor Negrín; 🇪🇸 Las Palmas De Gran Canaria, Las Palmas, Spain

Ángel Becerra; 🇪🇸 Las Palmas De Gran Canaria, Las Palmas, Spain