Beta2-mimetic and Central Nervous System: Effects of Salbutamol on Cortical Excitability and Cerebral Activation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Maximal voluntary activation
研究概览
简要总结
Beta2-mimetics such as Salbutamol have been shown to have ergogenic effects. Acute and chronic inhaled or oral doses of Salbutamol have been shown to increase whole body exercise and muscle performances. The underlying mechanisms are however unclear. Some data suggest that Salbutamol may have some effects on the central nervous system which may explain the improved exercise and neuromuscular performances. The present study aims to assess the effects of acite inhaled or oral Salbutamol intake on the neuromuscular system by using neurostimulation techniques and magnetic resonance imaging.
详细描述
The effects of Salbutamol intake will be assessed by using transcranial magnetic stimulation on one hand and magnetic resonance imaging on the other hand. Maximal voluntary activation and cerebral activation will be measured during motor tasks performed until exhaustion after acute inhaled slabutamol intake, acture oral salbutamol intake or oral placebo intake.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects without respiratory and cordiovascular diseases
- •Age between 18 and 35
- •Trained subjects (>6 hours of physical activity per week)
- •Non- or ex-smoker (smoking cessation since at least 1 year)
排除标准
- •Respiratory, cardiovascular and metabolic diseases
- •Neuromuscular diseases
- •thyrotoxicosis, or diabetes treated with insulin
- •alcoholism
- •MRI contraindication
- •TMS contraindication
研究组 & 干预措施
Inhaled Salbutamol
Acute inhalation of 800 microgram Salbutamol
干预措施: Salbutamol (Drug)
Oral Salbutamol
Acute oral intake of 4 mg Salbutamol
干预措施: Salbutamol (Drug)
Placebo
Acute oral intake of a placebo
干预措施: Placebo (Drug)
结局指标
主要结局
Maximal voluntary activation
时间窗: Measured immediatly after treatment intake (within 1 h)
Measurement performed by using transcranial magnetic stimulation, superimposed on submaximal and maximal quadricep contractions
次要结局
- Exercise endurance(Measured immediatly after treatment intake (within 1 h))
- Cortical activation(Measured immediatly after treatment intake (within 1 h))