NCT01957293已完成2 期
Influence of Salbutamol on Emotional and Cognitive Functions in Healthy Subjects
Prof. Dominique de Quervain, MD1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2013年10月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Change of episodic memory functions under Salbutamol
研究概览
简要总结
Aim is to investigate the effect of beta2 adrenergic stimulant salbutamol on emotional and cognitive functions in healthy humans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy, male and female, aged between 18 and 40, BMI be-tween 19 and 27 kg/m2, normotensive (BP between 90/60 mmHg and 140/90 mmHg), native or fluent German-speaking, caucasian (European ancestry), able and willing to give written informed consent and comply with the requirements of the study protocol, willing to donate saliva sample for DNA-analysis -
排除标准
- •Acute or chronic psychiatric or somatic disorder, tachycardia at rest (> 100 bpm), known hypersensitivity to salbutamol, pathological ECG, pregnancy, breast-feeding, long-term medication within last 3 months (oral contraceptives are disregarded) smoking (>3 cigarettes per day), concurrent participation in another study, participation in one of our previous studies using the same memory tests, inability to read and understand the participant's information. -
研究组 & 干预措施
Salbutamol
Experimental
干预措施: Salbutamol (Drug)
Sugar Syrup
Placebo Comparator
干预措施: Placebo (Drug)
结局指标
主要结局
Change of episodic memory functions under Salbutamol
时间窗: two testing days within10 days
memory tests
Change of emotional memory functions under Salbutamol
时间窗: two testing days within 10 days
memory tests
次要结局
- change of attention functions under salbutamol(two testing days within 10 days)
- Change of emotional state under salbutamol(Two testing days within 10 days)
研究者
Prof. Dominique de Quervain, MD
Director of teh Division of Cognitive Neuroscience
University of Basel
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Beta2-mimetic and Central Nervous SystemAdrenergic Beta-2 Agonist EffectAlbuterol EffectNCT02925130University Hospital, Grenoble15
已完成
不适用
Effect of inhaled airway widening medication on exhaled nitric oxide (an airway inflammation marker) in chronic obstructive pulmonary diseasechronic obstructive pulmonary diseaseRespiratory - Chronic obstructive pulmonary diseaseACTRN12616000140459niversity of Otago20
已完成
不适用
Influence of Inhaled Salbutamol on the Outcome of Transient Tachypnea of the NewborTransient tachypnoea of newborn.Transient tachypnoea of newbornIRCT2017062129336N3Vice Chancellor research of Ahvaz Jundishapur University of Medical Sciences148
已完成
不适用
Effects of inhaled salbutamol on specific fitness standards in professional soccers, a double-blind clinical trialIRCT201205098117N3Reserch deputy, Tehran University of Medical Sciences30
已完成
不适用
Autonomic Nervous System and Sickle Cell DiseaseHeart Rate Variability (ANS Function)NCT04062409Assistance Publique - Hôpitaux de Paris90