Influence of Salbutamol on Emotional and Cognitive Functions in Healthy Subjects

Phase 2

Completed

• Conditions: Memory Functions
• Interventions: Drug: Placebo; Drug: Salbutamol

• Registration Number: NCT01957293
• Lead Sponsor: Prof. Dominique de Quervain, MD

Brief Summary

Aim is to investigate the effect of beta2 adrenergic stimulant salbutamol on emotional and cognitive functions in healthy humans.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-09-24
• Study First Submitted QC: 2013-09-30
• Study Start: 2013-10
• Study First Posted: 2013-10-08
• Primary Completion: 2014-01
• Status Verified: 2014-02
• Study Completion: 2014-02
• Last Update Submitted: 2014-12-15
• Last Update Posted: 2014-12-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Healthy, male and female, aged between 18 and 40, BMI be-tween 19 and 27 kg/m2, normotensive (BP between 90/60 mmHg and 140/90 mmHg), native or fluent German-speaking, caucasian (European ancestry), able and willing to give written informed consent and comply with the requirements of the study protocol, willing to donate saliva sample for DNA-analysis -

Exclusion Criteria

Acute or chronic psychiatric or somatic disorder, tachycardia at rest (> 100 bpm), known hypersensitivity to salbutamol, pathological ECG, pregnancy, breast-feeding, long-term medication within last 3 months (oral contraceptives are disregarded) smoking (>3 cigarettes per day), concurrent participation in another study, participation in one of our previous studies using the same memory tests, inability to read and understand the participant's information. -

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Sugar Syrup	Placebo	-
Salbutamol	Salbutamol	-

Primary Outcome Measures

Name	Time	Method
Change of episodic memory functions under Salbutamol	two testing days within10 days	memory tests
Change of emotional memory functions under Salbutamol	two testing days within 10 days	memory tests

Secondary Outcome Measures

Name	Time	Method
change of attention functions under salbutamol	two testing days within 10 days	attention tests
Change of emotional state under salbutamol	Two testing days within 10 days	questionnaires

Trial Locations

Locations (1)

University of Basel, Division of Cognitive neuroscience; 🇨🇭 Basel, Switzerland