Sedation and Ease of Weaning From Mechanical Ventilation

Not Applicable

Completed

• Conditions: Midazolam Overdose; Respiratory Failure; Chronic Obstructive Pulmonary Disease; Weaning Failure
• Interventions: Drug: Daily interruption of midazolam

• Registration Number: NCT03406936
• Lead Sponsor: Assiut University

Brief Summary

Daily interruption of sedation is one of the modalities which is known to enhance early weaning and separation from mechanical ventilation . Daily sedation interruption is also known to help decreasing incidence of ventilator associated pneumonia. The new modality is no sedation.

Detailed Description

there is an increase of incidence of chronic obstructive lung disease associated respiratory failure which necessitates invasive mechanical ventilation. It is well known that one of the bundles for enhanced recovery of such cases is the daily interruption of sedation . Recently studies have demonstrated the feasibility of just using sedation for initiation of mechanical ventilation, then utilization of no sedation technique as a more this offers less side effects .

Study Timeline

• Study Start: 2016-08-20
• Primary Completion: 2017-06-28
• Study Completion: 2017-10-30
• Status Verified: 2018-01
• Study First Submitted: 2018-01-13
• Study First Submitted QC: 2018-01-20
• Last Update Submitted: 2018-01-20
• Study First Posted: 2018-01-23
• Last Update Posted: 2018-01-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Obstructive lung disease
• Respiratory failure
• Invasive mechanical ventilation

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Exclusion Criteria

• Neurological deficit
• Cognitive dysfunction
• Extensive malignancy
• septic Shock

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Daily interruption of sedation	Daily interruption of midazolam	Daily interruption of sedation will be done at 7 am daily by stoppage of midazolam infusion

Primary Outcome Measures

Name	Time	Method
duration of mechanical ventilation	first 30 days	number of days of mechanical ventilation

Trial Locations

Locations (1)

Emad Zarief Kamel Said; 🇪🇬 Assiut, Egypt