Study to treat patients with knee defects using adult stem cells
Phase 1
- Conditions
- Health Condition 1: null- Focal chondral defects in the knee
- Registration Number
- CTRI/2015/02/005568
- Lead Sponsor
- Aware Global Hospitals
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other (Terminated)
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
History of Grade III & IV defect on the medial or lateral femoral condyle or troclea,Failed prior treatment to articular defects of the knee
Exclusion Criteria
Alcohol or drug abuse during last 3 years,Inflammatory joint disease,Serious illness and infective etiology
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Treatment efficacy from the baseline in KOOS scoreTimepoint: 36 months
- Secondary Outcome Measures
Name Time Method Change status from baseline in quality of life by way of OA scoreTimepoint: 3 years
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular pathways are involved in autologous chondrocyte implantation for focal knee cartilage repair?
How does ACI compare to microfracture in treating focal chondral defects in phase I trials?
Which biomarkers correlate with successful cartilage regeneration in ACI-treated knee defects?
What are the long-term adverse events associated with autologous chondrocyte implantation in CTRI/2015/02/005568?
Are there combination therapies with growth factors or scaffolds enhancing ACI outcomes in knee cartilage repair?