Autologous chondrocyte transplantation/implantation versus existing treatments
- Conditions
- OrthopaedicsMusculoskeletal DiseasesChondral defect(s) in the knee
- Registration Number
- ISRCTN48911177
- Lead Sponsor
- Keele University (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 400
Current inclusion criteria as of 09/11/2012:
1. Symptomatic chondral defect(s) on the medical or lateral femoral condyle, trochlea or patella suitable for either ACT or one of the existing conventional treatments (debridement, abrasion, drilling, microfracture, mosaicplasty)
2. Surgical treatment for the same defect carried out at least 12 months previously, that has not relieved symptoms
3. Not more than two defects, not kissing and total area not greater than 12cm2
4. Likely to comply with appropriate physiotherapy
Previous inclusion criteria until 09/11/2012:
1. Symptomatic chondral defect(s) on the medical or lateral femoral condyle or trochlea suitable for either ACT or one of the existing conventional treatments (debridement, abrasion, drilling, microfracture, mosaicplasty)
2. Surgical treatment for the same defect carried out at least 12 months previously, that has not relieved symptoms
3. Not more than two defects, not kissing and total area not greater than 12cm2
4. Likely to comply with appropriate physiotherapy
1. Concurrent meniscectomy/osteotomy or untreated malalignment of patella
2. Generalised osteoarthritis, inflammatory condition or history of mesenchymal tumors
3. Patient in different clinical trial involving the knee, currently or in last 6 months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method