Ovarian Tissue Transplantation

Not Applicable

Recruiting

• Conditions: Infertile Females or Females With Ovarian Insufficiency

• Registration Number: NCT01870752
• Lead Sponsor: Abramson Cancer Center at Penn Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-6-4
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 10

Inclusion Criteria

Inclusion Criteria:<br><br> - Female patient between the ages of 18 and 45 years<br><br> - Previously cryopreserved and stored cortical ovarian tissue available for autologous<br> transplantation<br><br> - Ovarian insufficiency defined as an elevated FSH over 10<br><br> - Inability to conceive after 6 months of unprotected intercourse with male<br><br> - Reasonably good health<br><br> - Candidate for pregnancy<br><br> - Written clearance for the procedure from the patients oncologist<br><br>Exclusion Criteria:<br><br> - Patients considered to be high risk for surgical complications will be excluded from<br> the research protocol<br><br> - Women who are known to be positive for the BRCA mutation<br><br> - Women with a history of leukemia, ovarian cancer or a cancer that likely involved<br> the ovaries at the time of ovarian tissue collection<br><br> - Women with psychological, psychiatric, or other conditions which prevent giving<br> fully informed consent<br><br> - Current pregnancy

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pregnancy;Return of menstrual function

Secondary Outcome Measures

Name	Time	Method
Cancer recurrence;Surgical Complications of ovarian tissue transplantation;Acceptability