Extent of Lymph Node Dissection for Advanced Right-Sided Colon Cance

Not Applicable

Not yet recruiting

• Conditions: Advanced Right-sided Colon Cancer; the Extent of Lymph Node Dissection

• Registration Number: NCT06986538
• Lead Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University

Brief Summary

This is a prospective multicenter randomized controlled clinical study to explore the extent of lymph node dissection in progressive right hemicolon cancer and to elucidate the pattern of lymphatic drainage in the right hemicolon.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-04-15
• Status Verified: 2025-05
• Study First Submitted QC: 2025-05-22
• Last Update Submitted: 2025-05-22
• Study First Posted: 2025-05-23
• Last Update Posted: 2025-05-23
• Study Start: 2025-06-01
• Primary Completion: 2029-12-31
• Study Completion: 2029-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 1064

Inclusion Criteria

1. Age: 18-75 years
2. Preoperative pathologic confirmation of adenocarcinoma
3. Tumor located in the region from the ileocecal valve to the right one-third of the transverse colon
4. American Society of Anesthesiologists (ASA) physical status classification I to III
5. Patients who have not received preoperative radiotherapy, chemotherapy, or immunotherapy
6. Preoperative imaging staging cT4N0M0 or cT3-4N+M0
7. Willing to participate in the study and sign the informed consent form

Exclusion Criteria

1. Past medical history of malignant tumor
2. Patients with multiple primary tumors
3. Patients with a history of inflammatory bowel disease or familial adenomatous polyposis
4. Patients with distant metastasis
5. Pregnant or breastfeeding women
6. History of other previous major abdominal surgery
7. Patients requiring emergency surgery (including tumor perforation, obstruction, hemorrhage, etc.)
8. Those with other clinical and laboratory conditions deemed by the investigator to be inappropriate for participation in the trial

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Disease-Free Survival	The third postoperative year	It is defined as the proportion of patients from the start of randomization to the end of the third year without any of the following events: disease progression, local recurrence, distant metastasis, second primary colorectal cancer, or death from any cause.

Secondary Outcome Measures

Name	Time	Method
overall survival	The third postoperative year	The time from randomization to death from any cause.

Trial Locations

Locations (26)

Cancer Hospital, Chinese Academyof Medical Sciences; 🇨🇳 Beijing, Beijing, China

Peking University People's Hospital; 🇨🇳 Beijing, Beijing, China

Fujian Medical University Affiliated Union Hospital; 🇨🇳 Fuzhou, Fujian, China

Guangdong Provincial People's Hospital; 🇨🇳 Guangzhou, Guangdong, China

the First Affiliated Hospital of Sun Yat-sen University; 🇨🇳 Guangzhou, Guangdong, China

Sun Yat-sen University Cancer Hospital; 🇨🇳 Guangzhou, Guangdong, China

The First Affiliated Hospital of Guangzhou University of Chinese Medicine; 🇨🇳 Guangzhou, Guangdong, China

Nanfang Hospital, Southern Medical University; 🇨🇳 Guangzhou, Guangdong, China

Department of Coloretcal Surgery, the Sixth Affiliated Hospital of Sun Yat-sen University,; 🇨🇳 Guangzhou, Guangdong, China

Qingyuan People's Hospital; 🇨🇳 Qingyuan, Guangdong, China

Yuebei People's Hospital; 🇨🇳 Shaoguan, Guangdong, China

Zhaoqing First People's Hospital; 🇨🇳 Zhaoqing, Guangdong, China

The First Affiliated Hospital of Guangxi University of Chinese Medicine; 🇨🇳 Nanning, Guangxi, China

Guizhou Cancer Hospital; 🇨🇳 Guiyang, Guizhou, China

The First Affiliated Hospital of Zhengzhou University; 🇨🇳 Zhengzhou, Henan, China

The First Affiliated Hospital of Nanchang University; 🇨🇳 Nanchang, Jiangxi, China

The Second Affiliated Hospital of Nanchang University; 🇨🇳 Nanchang, Jiangxi, China

China-Japan Union Hospital of Jilin University; 🇨🇳 Changchun, Jilin, China

Shengjing Hospital of China Medical University; 🇨🇳 Shenyang, Liaoning, China

Qilu Hospital of Shandong University; 🇨🇳 Jinan, Shandong, China

Cancer Hospital of Fudan University; 🇨🇳 Shanghai, Shanghai, China

Shanghai Tenth People's Hospita; 🇨🇳 Shanghai, Shanghai, China

Changhai Hospitalof Naval Medical University; 🇨🇳 Shanghai, Shanghai, China

Shaanxi ProvincialPeople's Hospital; 🇨🇳 Xian, Shanxi, China

West China Hospital of Sichuan University; 🇨🇳 Chengdu, Sichuan, China

The First Affiliated Hospital of WenzhouMedical University; 🇨🇳 Wenzhou, Zhejiang, China