Effects of Positive Psychological Group Psychotherapy and Auricular Acupressure on Gambling Severity, Withdrawal Symptoms, and Dopamine
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Inha University Hospital
- Enrollment
- 240
- Locations
- 1
- Primary Endpoint
- Change from serum serotonin/dopamine levels during 6 months
Study Overview
Brief Summary
Objective The purpose of this study is to examine the effects of auricular acupressure and group counseling with positive psychology on gambling severity, withdrawal symptoms, and dopamine.
Methods This study is a randomized controlled trial and has been performed at a University in South Korea. 180 gamblers and 60 non-gamblers will be recruited. In the first year, gamblers will be randomly assigned to two groups: Experimental Group 1 (auricular acupressure); and Control Group 1 (education material to stop and cope withdrawal symptoms). And Normal Group will be recruited independently. Furthermore, a single blind randomized controlled trial will be performed in second and third year. And gamblers will be randomly assigned to three groups: Experimental Group 2 (auricular acupressure + group counseling); Placebo Group (placebo acupressure + group counseling); and Control Group 2 (education material to stop and cope withdrawal symptoms). Auricular acupressure using acupellets is performed for 6 weeks continuously.
Detailed Description
- Introduction The prevalence of gambling addiction is 4% in the U.S., 5.1% in South Korea. Furthermore gambling addiction causes more than 25 trillion in economic deficit annually, suicide and depression, and harmful social effects such as crime and divorce. According to a survey of 105 gambling addicts, 32.4% had depression, which is extremely high compared to 6.7% of the average person's prevalence of depression. Moreovermore, studies show that gambling addicts with depression have a higher level of addiction, childhood trauma experience, and higher nervousness and lower extroversion than those who are without depression. Gambling addicts scored higher than non-gambling addicts in anger. There is a high possibility of combined addiction and 83 studies of 11 addictions showed that gamblers were also addicted to alcohol and drugs about 36-59 percent. Those who had both gambling addiction and alcoholism had lower scores of stubbornness and cooperation compared to those who had only alcoholism. Both groups were anxious and fearful, and tended to pursue new stimuli, with low scores in self-directed areas. Online gambling addicts pursued new stimuli and showed stubborn personality traits compared to non-online gaming addicts.
Positive psychological mediation is a way to enhance strengths or positive emotions of gratitude, honesty, love, forgiveness, resistance, faith and so on, rather than focusing on the pathological part of the subject. According to an analysis of 22 Korean studies by Nami Kim, positive psychological mediation promoted physical, subjective, psychological and social welfare, and reduced depression, anxiety symptoms, and addiction. Gratitude scores were reported to have a negative correlation with the severity of gambling. The group that wrote five grateful things for two weeks everyday increased positive sentiment, subjective happiness, and decreased negative sentiment and depression compared to the group that recorded negative things or daily life. Forgiveness reduced stresses on self-criticism, resentment and reflection on past mistakes in subjects with drug addiction and suicidal idea. The seven sessions, consisting of forgiveness, gratitude, and recall of life, reduced anxiety and depression. Psychological resilience plays a role in buffering the correlation between gambling addiction and anxiety. Positive psychological intervention has been used to treat alcoholism, internet game addiction, drug addiction, and nicotine addiction, but has never been used to treat gambling addiction.
Auricular acupuncture is an alternative therapy that stimulates ears using seeds, magnets, stones, and metals. Furthermore, it has been used to treat nicotine and drug addiction, however, research into the problem of gambling has yet to be tried. Gambling subjects who received five weeks of body acupuncture, auricular acupuncture, auricular acupressure and counseling twice a week decreased in thrill-seeking(p=.01), gambling behaviors, ideas and desires, however, there were no statistically significant differences compared to a group who received counseling only (p=.08; effect size=0.64). As a result of applying auricular acupressure and positive psychological group counseling for quitting smoking for six weeks, withdrawal symptoms of experimental groups showed significant decrease compared to a placebo group. After a year, the smoking rate was 22.2 percent in an experimental group, 5.3 percent in a placebo group, and 5.6 percent in a control group.
And also gamblers experience withdrawal symptoms when gamblers try to quit gamble. To begin with, a study of withdrawal symptoms in 312 gambling addicts found that 25% experienced anxiety/annoyance and 41% experienced anger, guilt and disappointment. After examining the existence of gambling withdrawal symptoms tools for this study, it is believed that it is necessary to develop them and verify reliability and validity by referring to qualitative studies on gambling withdrawal symptoms and previously developed material addiction withdrawal tools.
Gambling addiction mechanism is as follows. Initially, gambling addiction has been reported to be linked to changes in neurotransmitters such as dopamine, serotonin and opioid. Furthermore, gamblers showed increased performance of dopamine in dynamic positron emission tomography compared to non-gambling addicts. Also, a comparison of problem and non-problem gamblers found that both groups had increased norepinephrine at the beginning of gambling, but maintained an increased norepinephrine throughout the gambling period. Meanwhile, the dopamine level of the problematic gamblers was significantly higher than that of non-problematic ones. Problematic individuals are more impulsive than those who do not have gambling problems, and blood serotonin and impulsiveness are reported to be negatively correlated.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Masking Description
In the first year, there is no masking to participant and researcher.
Eligibility Criteria
- Ages
- 19 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •gamblers who - are more than 19 years old
- •had a total gambling period of more than six months
- •gambled within a month
- •wanted to quit gambling
- •had eight or more PGSI(Problem Gambling Severity Index) scores
- •had no ear infections
- •were not allergic to copper or aluminum
- •willing to complete questionnaires
- •agreed to extract blood
- •non-gamblers who
- •were over the age of 19
- •willing to complete questionnaires
- •agreed to extract blood
- •got zero or received the lowest scores on alcoholism, smartphone addiction, game addiction, and gambling addiction tests
- •had never smoked
- •never been blacked out in their lives
- •had negative outcome in cotinine urine tests
- •had no medical or psychological diagnosis
- •no medication for therapeutic purposes
Exclusion Criteria
- •gamblers who - were pregnant - had experiences in taking drugs, including marijuana.
- •non-gamblers who
- •were pregnant
- •had taken painkillers in recent a week prior to blood testing
- •had experiences in taking drugs, including marijuana
- •[For second and third year]:
- •Inclusion Criteria:
- •will be the same as those in the first year of the study.
- •Exclusion Criteria:
- •gamblers who
- •were undergoing gambling counseling
- •were on medication
- •had taken painkillers in the past a week
- •were pregnant
- •had experiences in taking drugs, including marijuana
Outcomes
Primary Outcomes
Change from serum serotonin/dopamine levels during 6 months
Time Frame: baseline, 6 weeks, 6 months
A suitable sample is EDTA (WB). After calming the subjects for about 30 minutes, collect up to 12ml of peripheral blood through needles. Put the samples in an EDTA sample tube and apply them evenly on the wall of the tube, then centrifuge them for 7 minutes at 3000 rpm. Remove plasma immediately within one hour of collecting blood and store it at a temperature below minus 20 degrees Celsius.
Change from Gambling Withdrawal during 1 year
Time Frame: baseline, 2,3,4,5,6 weeks, 6 months, 1 year
Problem Gambling Severity Index was developed based on research into existing gambling withdrawal symptoms.The withdrawal symptoms include 14 items. Zero points have no withdrawal symptoms, one "very little" and two "nominal" and three "normal" and four "very severe". The score is between 0 and 56, and the higher the score, the worse the withdrawal symptoms. Reliability and validity will be checked in this study.
Change from Problem Gambling Severity during 1 year
Time Frame: baseline, 6 weeks, 6 months, 1 year
a tool used to identify gambling addiction, with a score range of 0-27 on the Likert scale of 9 questions which require a score of 0-3. The higher the score, the more serious the gambling addiction. Scores 1-2 are classified as low risk, 3-7 as medium risk, and 8 or more as problematic gambling.
Secondary Outcomes
- Resilience(baseline, 6 weeks, 6 months, 1 year)
- Korean Smartphone Addiction Proneness Scale for Adults(baseline)
- Patient Health Questionnaire-9(baseline, 6 weeks, 6 months, 1 year)
- Korean Version of Gratitude Questionnaire(baseline, 6 weeks, 6 months, 1 year)
- Korean version of Nicotine Dependence Syndrome Scale(baseline)
- Eysenck Personality Inventory(baseline)
- Korean Forgiveness Scale-Short Form(baseline, 6 weeks, 6 months, 1 year)
- Urine Cotinine Test(baseline)
- Korea Version of Alcohol Use Disorder Identification Test(baseline)
Investigators
EUN JIN LEE
Professor
Inha University Hospital
