Biomarkers for Pain in Spinal Cord Injury (SCI) Patients

Active, not recruiting

• Conditions: Traumatic Spinal Cord Injury; Neuropathic Pain
• Interventions: Other: blood samples

• Registration Number: NCT00913471
• Lead Sponsor: The University of Texas Health Science Center, Houston

Brief Summary

The investigators propose to compare plasma protein profiles for SCI patients with/without chronic neuropathic pain in order identify biomarker(s) that are associated with this medical condition. Secondly, the investigators propose to identify a temporal relationship to initial SCI at which these biomarkers manifest.

Our working hypothesis is that sustained alterations in specific inflammatory molecules are associated with chronic neuropathic pain following SCI, and that their plasma levels can serve as biomarkers to identify patients at risk for the development of neuropathic pain.

Additionally the investigators are collecting skin tissue biopsy samples from patients following acute and chronic spinal cord injury to create vector-free human iPS cells from fibroblasts by direct delivery of reprogramming proteins.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-06
• Study First Submitted: 2009-06-02
• Study First Submitted QC: 2009-06-03
• Study First Posted: 2009-06-04
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-22
• Last Update Posted: 2024-08-23
• Primary Completion: 2030-06
• Study Completion: 2030-12

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Chronic SCI	blood samples	-
Acute-Longitudinal SCI	blood samples	-
Healthy volunteers	blood samples	-

Primary Outcome Measures

Name	Time	Method
To identify candidate biomarkers for pain in the chronic SCI samples.	two or more years post injury

Secondary Outcome Measures

Name	Time	Method
To identify the temporal relationship of the development of pain and the manifestation of the biomarkers identified	two or more years post injury

Trial Locations

Locations (1)

Memorial Hermann Hospital; 🇺🇸 Houston, Texas, United States