Biomarkers for Pain in Spinal Cord Injury (SCI) Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Traumatic Spinal Cord Injury
- Sponsor
- The University of Texas Health Science Center, Houston
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- To identify candidate biomarkers for pain in the chronic SCI samples.
- Status
- Active, not recruiting
- Last Updated
- 8 months ago
Overview
Brief Summary
The investigators propose to compare plasma protein profiles for SCI patients with/without chronic neuropathic pain in order identify biomarker(s) that are associated with this medical condition. Secondly, the investigators propose to identify a temporal relationship to initial SCI at which these biomarkers manifest.
Our working hypothesis is that sustained alterations in specific inflammatory molecules are associated with chronic neuropathic pain following SCI, and that their plasma levels can serve as biomarkers to identify patients at risk for the development of neuropathic pain.
Additionally the investigators are collecting skin tissue biopsy samples from patients following acute and chronic spinal cord injury to create vector-free human iPS cells from fibroblasts by direct delivery of reprogramming proteins.
Investigators
Georgene Hergenroeder
Associate Professor, Neurosurgery
The University of Texas Health Science Center, Houston
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
To identify candidate biomarkers for pain in the chronic SCI samples.
Time Frame: two or more years post injury
Secondary Outcomes
- To identify the temporal relationship of the development of pain and the manifestation of the biomarkers identified(two or more years post injury)