The Primary Objective of This Study Was to Investigate the Effect of Insulin on Myocardial Perfusion and Cardiac Function in Patients Undergoing Cardiac Surgery for CPB Using Transesophageal Echocardiography (TEE) to Detect CSBF

Not Applicable

Completed

• Conditions: Insulin
• Interventions: Drug: Glucose insulin potassium

• Registration Number: NCT05464966
• Lead Sponsor: Yangzhou University

Brief Summary

The primary objective of this clinical trial was to investigate the effects of insulin on myocardial blood flow reflected by CSBF which was evaluated by TEE. The second aim was to observe the effect of insulin on cardiac function and markers of myocardial damage.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-05-15
• Study Start: 2022-06-01
• Study First Submitted QC: 2022-07-17
• Study First Posted: 2022-07-19
• Primary Completion: 2023-05-31
• Study Completion: 2023-06-30
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-18
• Last Update Posted: 2024-01-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Glucose-insulin-potassium	Glucose insulin potassium	-

Primary Outcome Measures

Name	Time	Method
Changes in the coronary sinus blood flow spectrum	from 30 minutes after intubation to 1 hour after intubation , from 30minutes before the end of the surgery to the end of the surgery	coronary sinus blood flow spectrum changes such as SVTI、DVTI、AVTI are assessed by TEE
Changes in left ventricular diastolic function	from 30 minutes after intubation to 1 hour after intubation , from 30minutes before the end of the surgery to the end of the surgery	Changes in left ventricular diastolic function are assessed by TEE, such as changes in pulmonary venous blood flow

Secondary Outcome Measures

Name	Time	Method
Changes in the level of SVR	into ICU 30 minutes	The above results should be measured immediately after induction, at the beginning of surgery, after administration of protamine, and at the end of surgery
Changes in the level of Cardiac output	into ICU 30 minutes	The above results should be measured immediately after induction, at the beginning of surgery, after administration of protamine, and at the end of surgery
Changes in the level of Systolic Blood Pressure/Diastolic Blood Pressure(Mean Arterial Pressure)	into ICU 30 minutes	The above results should be measured immediately after induction, at the beginning of surgery, after administration of protamine, and at the end of surgery
Changes in the level of SVRI	into ICU 30 minutes	The above results should be measured immediately after induction, at the beginning of surgery, after administration of protamine, and at the end of surgery
Changes in the level of Heart Rate	into ICU 30 minutes	The above results should be measured immediately after induction, at the beginning of surgery, after administration of protamine, and at the end of surgery
Changes in the level of Cardiac index	into ICU 30 minutes	The above results should be measured immediately after induction, at the beginning of surgery, after administration of protamine, and at the end of surgery

Trial Locations

Locations (1)

the Affiliated Hospital of Yangzhou University, Yangzhou University; 🇨🇳 Yangzhou, Jiangsu, China