Mineral-Nano-Pathology : Wear of Hip Implants
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Arthroplasty
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 135
- Locations
- 2
- Primary Endpoint
- types of particles that cause the most tissue inflammation
- Status
- Completed
- Last Updated
- 4 months ago
Overview
Brief Summary
Hip arthroplasty is a treatment widely used in most inflammatory, traumatic and degenerative conditions of this joint. The longevity of implants may be disappointing in some cases, despite the promising results obtained during in vitro simulations. Early loco-regional or systemic dissemination, known since the 1990s, of wear particles from these prosthesis may reduce their life span.
The analysis of the particles in the synovial fluid and in the articular tissues by electron microscopy after digestion or directly by optical microscopy, will improve the knowledge on the mechanisms of wear.
This category 3 study is based on the case-control model and will be conducted in a national reference center (hospital la Croix-Rousse- Lyon). It will include a population of adult patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adult patient,
- •Patient including French,
- •Patient witness: to be hospitalized in the orthopedic department of the Croix-Rousse hospital for a first hip prosthesis
- •Patient test: to be hospitalized in the orthopedic department of the Croix-Rousse hospital for the removal of a hip prosthesis
Exclusion Criteria
- •Patient protected by law (guardianship, curatorship, safeguard of justice).
- •Pregnant or lactating woman
- •Patient with suspicion of infection on prosthesis
- •Patient opposing his participation in the study
Outcomes
Primary Outcomes
types of particles that cause the most tissue inflammation
Time Frame: day of surgery
Types of wear particles most found in patients whose tissues are classified as inflammatory. The particles can be classified by size, shape, material and type of original prosthesis.