Do older people experience a greater post-meal inflammatory response to a fast food breakfast?

Not Applicable

Completed

• Conditions: senescence; cardiovascular disease; inflammation; Diet and Nutrition - Other diet and nutrition disorders; Cardiovascular - Coronary heart disease; Inflammatory and Immune System - Other inflammatory or immune system disorders

• Registration Number: ACTRN12612000515897
• Lead Sponsor: David Cameron-Smith

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-05-15
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Aged 20-25 or 70-75 years old
Non-vegetarian
No allergies to peanuts, dairy, gluten

Exclusion Criteria

Vegetarian
Food allergies to peanuts, dairy, gluten
Family history of diabetes
Family history of heart disease
Anti-inflammatory pharmaceutical use
BMI >30

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Inflammatory cytokine profile of IL-6, IL-1, TNF-a, MCP-1 and CRP as measured by immunolite fluorescent analysis in plasma samples.[Baseline, and at 30 minute intervals for 5 hours.];Chylomicron size distribution as measured by laser diffraction particle size analysis.[Baseline, and at 1 hour intervals for 5 hours.]

Secondary Outcome Measures

Name	Time	Method
Endotoxin concentration as measured by Limulus amoebocyte lysate assay.[Baseline, and at 1 hour intervals for 5 hours.];Peripheral Blood Mononuclear Cell (PBMC) gene expression as measured by oligonucleotide microarray.[Baseline, and at 30 minute intervals for 5 hours.];Plasma amino acid, glucose and fatty acid profile by gas chromatography spectrometry.[Baseline, and at 30 minute intervals for 5 hours.];Plasma insulin, GLP-1 and glucagon as measured by immunoassay.[Baseline, and at 30 minute intervals for 5 hours.]