Pregabalin and Hypotensive Anesthesia

Not Applicable

Recruiting

• Conditions: Nervous System Diseases; Surgery; spine surgery

• Registration Number: PACTR201710002516280
• Lead Sponsor: faculty of medicine, Mansoura universisty

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-08-14
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 106

Inclusion Criteria

aged 18¿55 years,
- American Society of Anesthesiologists (ASA) score I-II
- admitted to undergo elective lumbar discectomy or spinal fixation surgery under general anesthesia

Exclusion Criteria

- Patients on anti-hypertensive treatment, diuretics, corticosteroids, pregabalin, gabapentin, anticonvulsants, antipsychotics, alcohol addiction, drug abuse or any analgesics within 48 hours before surgery.
- patients with history of allergy to any drug used in the study.
- pregnant or nursing women.
- patients with peripheral neuropathy, endocrinal diseases, bleeding abnormality, cardiac, hepatic or renal impairment.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Intraoperative consumption of nitroglycerin to maintain the target MAP 55- 65 mmHg.

Secondary Outcome Measures

Name	Time	Method
estimated blood loss ;The number of transfused blood unites;heart rate (HR) and invasive MAP;end-tidal isoflurane concentration;Surgeon satisfaction about the field (scale 0-5);Sedation (by Ramsay sedation scale);The time to the first request of analgesia.;Postoperative pain (by VAS 0-10 scale);The total morphine consumption;Frequency of adverse effects as dizziness, headache, nausea and vomiting, or pruritus.;Peak and plateau airway pressures