A comparison of intravenous salbutamol and aminophylline in the management of acute severe asthma in childre
Completed
- Conditions
- AsthmaRespiratory
- Registration Number
- ISRCTN65396765
- Lead Sponsor
- HS R&D Regional Programme Register - Department of Health (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
1. Age 1 to 15 years
2. Acute severe asthma with an asthma severity score of greater than 7
3. Poor response to 3 back to back salbutamol/ipratropium nebulisers with an improvement in asthma severity score of less than 2
Exclusion Criteria
1. A life threatening exacerbation
2. An underlying respiratory disease other than asthma
3. Cardiac disease
4. Treatment with a medication that alters the metabolism of aminophylline
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Duration of the need for supplementary oxygen to maintain saturations of above 91%.
- Secondary Outcome Measures
Name Time Method Other end points:<br>1. Asthma severity score two hours after starting intravenous therapy<br>2. Time to stopping intravenous therapy<br>3. Time to decision to discharge subject