Comparative evaluation of remineralization efficacy Nanohydroxyapatite and Bioactive glass on demineralized enamel – An in situ study
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Vicker’s microhardness values
研究概览
简要总结
This is an in-situ study comparing theefficacy of biomimetic (nanohydroxapatite) and non biomimetic remineralizingagents (bioactive glass) on demineralized enamel slabs obtained from extractedhuman third molar teeth (cleaned and autoclaved).
In-Situstudy design: Theremineralization phase will take place in the oral cavity of healthy volunteersunder the influence of saliva.
Six healthy adultvolunteers (post graduate dental students) will take part in a 7 days in-situ studyafter giving consent. They will wearacrylic palatal appliances, with each appliance containing two rows of three demineralizedenamel slabs. One row slabs will be treated using biomimetic remineralizationsystem (Nanohydroxyapatite - Group I) and the other row slabs will receivenon-biomimetic remineralization systems (Bioactive glass - Group II) for 7 days. A part ofthe enamel slab will serve as its own control (Baseline and demineralization).After the completion of remineralization cycle, Vickers microhardness values will be calculated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Not Applicable
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 35.00 Year(s)（—）
- 性别
- All
入选标准
- •Participants with good oral hygiene, Participants with a salivary pH ranging between 6.8 – 7.2, Participants with salivary flow above 1.0ml/min Presence of atleast 22 natural teeth with no caries activity or periodontal disease.
排除标准
- •Participants with poor oral hygiene Participants with very high caries activity Participants with less than 22 teeth Participants on antimicrobial or any other treatment.
结局指标
主要结局
Vicker’s microhardness values
时间窗: 7 days after remineralization
次要结局
- NA(NA)