NCT04074538招募中不适用
The National Colorectal Cancer Cohort Study-Precision Medical Research in Colorectal Cancer
Ding Ke-Feng5 个研究点 分布在 1 个国家目标入组 55,000 人开始时间: 2013年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 55,000
- 试验地点
- 5
- 主要终点
- Recurrence/metastasis
研究概览
简要总结
NCRCC study is a national prospective cohort study including colorectal cancer screening population and stage Ⅰ-Ⅳ colorectal cancer patients.
详细描述
NCRCC study is a large-scale multicenter study which includes 16 hospitals and research centers, establishing a national cohort which consists of two subcohorts (CRC Screening Cohort and Colorectal Cancer Patient Cohort).
- To assess risk factors for colorectal cancer and evaluate risk prediction model of colorectal cancer to identify the high-risk population.
- To discover, test and validate new biological markers (e.g. genetic, epigenetic, transcriptomic, metabolomics, proteomic and metagenomics biomarkers) for early diagnosis, prediction of clinical outcomes (e.g. therapeutic response, toxicity, surgical complications) and survivorship endpoints (e.g. recurrence, survival, quality of life, second primary cancer).
- To estimate associations of epidemiological determinants (e.g. medication and supplement use, diet, lifestyle pattern) with clinical outcomes and survivorship endpoints among CRC patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and women
- •Mentally/physically able to consent and participate
- •Subjects aged ≥18 years old (Colorectal Cancer Patient Cohort, CRCPC), age 40-74 years (CRC Screening Cohort, CRCSC)
- •Newly-diagnosed colon and rectal cancer for stages Ⅰ-Ⅳ (CRCPC)
排除标准
- •A history of colorectal cancer or bowel resection
- •Non-Chinese speaking
结局指标
主要结局
Recurrence/metastasis
时间窗: up to 5 years
colorectal cancer incidence
时间窗: up to 15 years
Disease-free and overall survival
时间窗: up to 10 years
Adenoma or advanced adenoma incidence
时间窗: up to 1 year
次要结局
- Second primary cancer incidence(up to 15 years)
- Prevalence of treatment-related toxicities characterized by the Common Toxicity Criteria for Adverse Events (CTCAE)(up to 5 years)
研究者
Ding Ke-Feng
Professor
Zhejiang University
研究点 (5)
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