Overnight Fasting After Completion of Therapy: The OnFACT Study

Not Applicable

Active, not recruiting

• Conditions: Childhood Cancer Survivors

• Registration Number: NCT03523377
• Lead Sponsor: Memorial Sloan Kettering Cancer Center

Brief Summary

The purpose of this study is to test whether regularly not eating for at least 14 hours overnight ("intermittent fasting") is feasible and can improve blood sugar.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-04-27
• Study First Submitted: 2018-05-01
• Study First Submitted QC: 2018-05-01
• Study First Posted: 2018-05-14
• Status Verified: 2025-07
• Last Update Submitted: 2025-07-24
• Last Update Posted: 2025-07-25
• Primary Completion: 2026-04
• Study Completion: 2026-04-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Body mass index is ≥ 18.5 kg/m^2
• History of treatment for cancer or related illness diagnosed at ≤ 25 years old
• Off cytotoxic therapy for primary cancer ≥ 2 years
• Not receiving cytotoxic therapy (chemotherapy, external beam radiation therapy) at the time of study enrollment
• History of radiation to the chest, abdomen or total body
• Current age ≥18 years
• English-speaking
• Personal phone with SMS text messaging capability
• Willingness to wear an mHealth device, such as a FitBit, for two 7-day periods
• Able to perform all study requirements

Exclusion Criteria

• Use of any antidiabetic, weight loss, or appetite control medication
• Use of any other medication that could impact dietary intake, such as prednisone
• Currently fasts 12 hours or more by self-report
• Unable to fast due to medical reason such as pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Participation completion	6 months	Proportion of registered participants who successfully complete the 6-month intervention

Secondary Outcome Measures

Name	Time	Method
measure of glucose metabolism	6 months	Assess the effect of prolonged overnight fasting on glucose metabolism, measured by glycosylated hemoglobin (HbA1c).

Trial Locations

Locations (1)

Memorial Sloan Kettering Cancer Center; 🇺🇸 New York, New York, United States