Effects of a low-fat vs a high-fat diet on lipid accumulation in liver, skeletal muscle and heart in overweight ma

Completed

• Conditions: diabetes; type 2 diabetes mellitus; 10018424

• Registration Number: NL-OMON33743
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 28

Inclusion Criteria

• Male sex
• Age 18-65 years
• BMI 25-35 kg/m2
• Sedentary
• Stable dietary habits
• Healthy
• Not wanting to be informed about a conincedence finding.

Exclusion Criteria

• Current use of medication that is known to interfere with the results of the study.
• Consuming more than 20 g of alcohol per day (± 2 units)
• Serum-γ-glutamyltranspeptidase level > 70 IU/L
• A history of cardiovascular disease like congestive heart failure or acute myocardial infarction
• Plasma triacylglycerol > 4.5 mmol/L
• Familial hypercholesterolemia
• A history of liver disease
• Unstable body weight (weight gain or loss > 3 kg in the past three months)
• Abuse of drugs
• Participation in another biomedical study within 1 month prior to the screening visit
• Impossible or difficult venipuncture during screening
• a fasting glucose above 7.0 mmol/L
• a contraindication to MRI scanning. These contraindications include patients with the following devices:
o Central nervous system aneurysm clips;
o Implanted neural stimulator;
o Implanted cardiac pacemaker or defibrillator;
o Cochlear implant;
o Ocular foreign body (e.g. metal shavings);
o Insulin pump;
o Metal shrapnel or bullet;
o Or metal containing corpora aliena in the eye of brains

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameter is the difference in insulin sensitivity after a switch<br /><br>from a low-fat diet to a high-fat diet compared to the control group, which<br /><br>stays on a low-fat diet. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>As secondary endpoints differences in lipid accumulation in heart liver and<br /><br>muscle, cardiac function, the time-course of lipid accumulation and the<br /><br>relationship between the tissue parameter lipid accumulation and the functional<br /><br>outcome parameter insulin resistance are considered.</p><br>